Tox Test 4
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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| What is heroin? | A semi-synthetic opiate synthesized from morphine
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| What are the routes of administration for heroin? | Mainly IV
Snorting
Smoking
Subcutaneous (skin popping)
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| What are the metabolites of heroin? | 6-monoacetylmorphine (6-MAM) and morphine
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| What is the half life of heroin? | 2-6 minutes
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| What are the metabolites of morphine? | morphine-3-glucoronide (M3G)
morphine-6-glucoronide (M6G)
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| Describe the distribution of 6-MAM. | 6-MAM is more lipid soluble than morphine and corsses teh blod-brain barrier more readily.
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| How is morphine eliminated? | 90% is eliminated in the urine in 72 hours.
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| What is the mechanism of action for heroin? | Heroin metabolites affect CNS through mu, kappa, and delta opiate receptors.
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| What are the effects of heroin? | analgesia, respiratory depression, euphoria, sedation, delusions, hallucinations, decreased gastrointestinal activity
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| What are the short term effects of heroin? | euphoria, alternately alert/drowsy state, dry mouth, warm skin, slowed breathing, muscular weakness
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| What are the long term effects of heroin? | addiction, tolerance, dependence, collapsed veins, heart lining/valve infection, pneumonia, decreased liver function, abcesses
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| Why could the incidences of heroin use be increasing? | higher purity product available, cheaper than prescription drugs, other drugs can't be taken by IV, use at younger age
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Created by:
bdcox15
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