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Lecture 1

Quiz yourself by thinking what should be in each of the black spaces below before clicking on it to display the answer.
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Question
Answer
List constitutional (non specific) symptoms   Fever ( T >37oC = 98.6oF), Headaches, myalgias, chills, nausea, sweating, mental status changes (confusion), dehydration and delirium in severe cases; Swelling, erythema, tenderness, purulent discharge, sputum production; ↑ WBC (high percentage of neutrop  
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Gram negative cocci (2)   Morexella catarrhalis, Neisseria meningitidis  
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Gram negative bacilli (8)   Enterobacter spp., Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, Legionella spp., Proteus mirabilis, Pseudomonas aeruginosa, Serratia marcescens  
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Gram positive cocci (3)   Enterococcus spp., Staphylococcus spp., Streptococcus spp.  
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Gram positive bacilli (2)   Clostridium spp., Listeria monocytogenes  
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Misc/Atypical bacteria   Mycoplasma pneumoniae, Chlamydiae spp., Borrelia burgdorferi, Treponema pallidum  
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Classification of Morexella catarrhalis   Gram negative cocci  
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Classification of Neisseria meningitidis   Gram negative cocci  
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Classification of Enterococcus spp.   Gram positive cocci  
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Classification of Staphylococcus spp.   Gram positive cocci  
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Classification of Streptococcus spp.   Gram positive cocci  
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Classification of Enterobacter spp.   Gram negative bacillus  
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Classification of Escherichia coli   Gram negative bacillus  
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Classification of Haemophilus influenzae   Gram negative bacillus  
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Classification of Klebsiella pneumoniae   Gram negative bacillus  
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Classification of Legionella spp.   Gram negative bacillus  
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Classificaiton of Proteus mirabilis   Gram negative bacillus  
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Classification of Pseudomonas aeruginosa   Gram negative bacillus  
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Classification of Serratia marcescens   Gram negative bacillus  
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Viruses   Herpes simplex virus, cytomegalovirus, HIV, hepatitis, influenzae, GI viruses, mumps, measles, rubella, small pox  
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Fungi   Candida spp, Cryptococuss spp., Histoplasma spp, blastomyces spp, Aspergillus's spp, dermatophytes, Pneumocystis jeroveci  
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Parasites   Toxoplasmosis, Giardia spp, Entomoeba spp, Trichomoniasis  
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Severe Inflammatory Response Syndrome (SIRS)   ≥ 2 or more: T >38 C, HR >90 bpm, RR >20 or PCO2 <32mm Hg, WBC >12K or >10% bands  
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Sepsis   SIRS with identified infection  
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Severe Sepsis   Hypoperfusion (lactic acidosis, renal failure, mental status changes); Hypotension  
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Septic shock   Severe sepsis with hypotension unresponsive to fluids, systolic BP <90 mm Hg  
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Classification of Clostridium spp.   Gram positive bacillus  
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Classification of Listeria monocytogenes   Gram positive bacillus  
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Βeta-lactams include these four subclasses   Penicillins, Cephalosporins, Monobactams, Carbapenems  
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Penicillins - spectrum   Mostly Gram-positive, but newer agents are more broad spectrum  
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Cephalosporins - 1st generation spectrum   mostly gram positive  
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Cephalosporins - 2nd generation spectrum   gram positive, some resistant gram negative, and anaerobes  
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Cephalosporins - 3rd and 4th generation spectrum   broader spectrum  
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Monobactams   Broad spectrums with anaerobes  
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Carbapenems   Broad spectrums with anaerobes  
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Aminoglycosides   Gram negative  
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Fluoroquinolones   Broad spectrum with atypicals coverage  
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Macrolides   Mostly gram positive, Selective Gram negative, Atypical coverage  
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Tetracycline   Broad spectrum with anaerobes  
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