WVSOM -- Fatty Acid Synthesis
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
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| When does FA synthesis occur? | When there are more calories ingested than are needed
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| Beginning Product of FA synthesis | Citrate
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| Citrate converted into what two products in preparation for FA synthesis | Oxaloacetate and Acetyl CoA
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| Acetyl CoA goes to what | Malonyl CoA
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| Malonyl CoA | 3 Carbon compound needed for the immediate sgtarting material for FA synthesis
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| What cofactor is needed in all carboxylases? | biotin
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| Fate of oxaloacetate from citrate lyase reaction | Oxaloacetate -> Malate -> Pyruvate
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| Location of FA synthesis | Hepatic cytosol
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| When is FA synthesis active | Fed state assuming excess calories present
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| FA synthesis Starting material | NADPH
Malonyl CoA
Acetyl CoA
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| FA Synthesis Products | NADP+
Palmitate
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| Process of FA synthesis | Reduction of carbons/oxidation of NADPH (reverse B oxidation)
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| Where do we get NADPH? | Pentose Phosphate Pathway
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| Fatty Acid Synthase | large complex of enzymes that binds growing acyl chain and malony CoA in first round.
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| Why is malonyl CoA used rather than acetyl coa? | allows regulation
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| Fate of new synthesized FA | activated to fatty acyl CoA for TG synthesis and incorporated into VLDL
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Created by:
tjamrose
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