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VM 607

Quiz yourself by thinking what should be in each of the black spaces below before clicking on it to display the answer.
        Help!  

Question
Answer
Metronidazoles   Nitroimidazoles - DNA damaging  
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Rifampin   Rifamycins- RNA synthesis inhibitor  
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Enfrofloxacin, ciprofloxacin, marbofloxacin, orbafloxacin   Floroquinolones - DNA replication inhibitors  
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Nitrofurantoin   Nitrofurnas - energy production pathway  
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Trimethoprim, ormetoprim   Diaminopyrimidines - folic acid pathway  
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Sulfamethoxazole, sulfadiazine, sulfadimethoxine   Sulfonamides - folic acid pathway  
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Chloramphenicol, florfenicol   Phenicols - 50 s protein synthesis inhibitor  
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Lincomycin, clindamycin, pirlimycin   Lincosamides - 50s protein synthesis inhibitor  
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Erythromycin, spiramycin, tulathromycin, tylosin, tilmicosin   Macrolides - 50 s protein synthesis inhibitors  
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Tetracycline, oxytetracyclin, chlortetracycline, doxycycline   Tetracylines- 30 s protein synthesis inhibitor  
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Streptomycin, spectinomycin, neomycin, gentamicin, amikacin   Aminoglycosides - 30 s protein synthesis inhibitors  
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Bacitracin   Bacitracin - cell wall synthesis inhibitor  
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Polymyxin B   Polymyxins - cell membrane disruptor  
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Vancomycin   Glycopeptides - inhibits cell wall synthesis  
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Aztreonam   Monbactams - B-lactam group  
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Imipenem   Carbapenems - B-lactam group  
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Clavulanic acid, sulbactam   B-lactamase inhibitors - B-lactam group  
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Ceftiofur, ceftazidime, cefovecin, ceftriaxone   3rd generation cephalosporins  
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Cefuroxime, cefotetan   2nd generation cephalosporins  
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Cefazolin, cephalexin, cephaloridine   1st generation cephalosporins  
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Ticarcillin, pipercillin   Extended spectrum penicillins  
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Methacillin, oxacillin   B lactamase resistant penicillins  
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Amoxicillin, ampicillin   Aminopenicillins  
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Penicillin G, penicillin V   Basic penicillin  
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Inactivated by acidic environment   Penicillin, cephalosporins, aminoglycosides, macrolides  
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Mineral interactions   Floroquinolones, tetracyclines, aminoglycosides  
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Allergies   Penicillins, cephalosporins, nitrofurans, sulfonamides  
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Poor tissue penetration   Penicillin, aminoglycosides, nitrofurans  
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Mycoplasma treatment   Macrolides, tetracycline, floroquinolone (back up)  
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Poor oral bioactivity   Penicillin, sulbactam, bacitracin, aminoglycosides (except neomycin)  
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Bone marrow toxicity   Chloramphenicol, rifampin  
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Banned in food animals   Banned: Vancomycin, chloramphenicol, rifampin, metronidazole, nitrofuran. Banned-off label: Cephalosporin, floroquinolones, sulfonamides (dairy cattle). Aminoglycosides - vet med ban  
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Neurotoxicity   Floroquinolone and metronidazole  
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Teratogenic   Metronidazole, rifampin, vancomycin  
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NOT empirical   Extended Spectrum pen, Carbapenems, Monobactams, Glycopeptides, Fluoroquinolones, Nitrofurans  
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