| Question |
 |
|
| Answer |
|
|
| blastomycoses |
ulcerative skin and bone lesions |
| W-1 glycoprotein surface antigen |
blastomycoses |
| chicago disease |
blastomycoses |
| cave/spelunker`s disase |
histoplasmosis |
| leads to pericarditis amd mediastenal fibrosis |
histoplasmosis |
| granulomas and TB-like lesions |
histoplasmosis |
| dematiaceous fungi |
Chromoblastomysosis |
| cauliflower-like wart lesions |
Chromoblastomysosis |
| might be treated with chemotherapy or surgery |
Chromoblastomysosis |
| long hyphae with rosetta pattern |
Lymphocutaneous Sporotrichosis |
| thick walls, rough macro and rare micro |
Microsporum |
| thin walls, smooth marco, many micro |
Trichophyton |
| smooth macro, no micro |
Epidermophyton |
| tinea capitis Tx |
griseofulvum |
| dont normally elicit IM response |
Superficial mycoses |
| spaghetti and meatball fungus |
Malassezia furfur (-> versicolor) |
| painful ulcers of oral , nasal, GI mucosa |
paracoccidiomycosis |
| chiefly affects men |
paracoccidiomycosis |
| endemic in S. America |
paracoccidiomycosis |
| desert rheumatism |
coccidiomycosis |
| fungus spread by dust storms |
coccodiomycosis |
| virulence via arthroconidia |
coccodiomycosis |
| urease -> alkaline halo |
coccodiomycosis |
| clacification of infected lesions |
coccodiomycosis |
| C. immitis |
coccodiomycosis |
| most prevalent fungal pathogen in the US |
cryptococcis |
| found in droppings of pigeons and eucalyptus |
cryptococcis |
| only exist in yeast form |
cryptococcis |
| contain capsule (unique for fungi) |
cryptococcis |
| produce melanin |
cryptococcis |
| pneumonia and lung nodules |
cryptococcis |
| might lead to meningtis |
cryptococcis |
| lung cancer-like lesion |
cryptococcis |
| alfatoxin |
aspergillosis |
| induce hepatoma |
aspergillosis |
| fungus balls = mycetoma |
aspergillosis |
| exist only in hyphal state |
aspergillosis |
| via BV -> brain |
aspergillosis |
| gliotoxin |
aspergillosis |
| diabetes, leukopeina |
zygomycosis |
| rhinocerebral form -> 85% mortality |
zygomycosis |
| most common resp infection in late state HIV |
pneumocystis jirveci |
| can transmit from human to human |
pneumocystis jirveci |
| not very responsive to anti-fungal Tx |
pneumocystis jirveci |
| exist in pulm interstitial tissue (sporocyst) |
pneumocystis jirveci |
| ground glass appearance on lung X-ray |
pneumocystis jirveci |
| death from asphyxiation |
pneumocystis jirveci |
| disrupt heme P-450 |
azoles |
| dont absorb from the gut |
polyenes |
| requires acidic pH (oral med) |
ketoconazole |
| 5-flurocytosine |
nucleoside analog |
| drug: enters CSF |
5-flurocytosine |
| drug: interact with tubulin (protein involved in Mit) |
griseofulvin |
| drug: interferes with CW synthesis |
echinocandins: caspofungin |
| candida reproduction |
Asexual budding |
| candida yeast form |
blastospore/conidia |
| candida hyphal form |
aka mycelial (germ tubes or pseudohyphae) |
| anaerobes |
candida |
| tolerates pH from 2 to 9 |
candida |
| denture wearers + salivary hypofxn |
candida glabrate |
| steroids act as nutrients for |
candida |
| localized, painless hyperemia on the palate |
chronic erythematous candidiasis |
| perleche |
erythematous areas at the corners of mouth |
| perleche |
angular chelitis |
| tissue damage by hyphal invasion of heart, SC, urethra |
systemic candidiasis |
| candida attachment |
fibronectin and laminin on damaged tissue |
| secretes aspartic proteinase and lipase |
candida |
| most effective anti-candida IM reponse |
PMN`s or CMI |
| high frequency phenotopic switching |
candida |
| germ tube formation |
candida |
| chlamydospores |
candida |
| 2 swish and swallow drugs |
Nystatin and clotrimazole |
Ch.18 LTI-MA 509
