chap 30
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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| Aspirin indications | pain, fever, inflammation
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| Aspirin indications | myocardial infarction, stroke, throboembolic disorder
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| aspirin contraindication | not used in children bc it causes Reye's syndrome
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| aspirin adverse effects | gastric irritation
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| aspirin adverse effects | GI bleeding and peptic ulcers
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| aspirin adverse effects | Tinitus (abnormal auditory sensation or buzzing noise)
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| salicylates adverse effects (aspirin) | fever
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| salicylates adverse effects (aspirin) | dehydration
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| salicylates adverse effects (aspirin) | severe metabolic acidosis
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| excessive doses of aspirin | hypoprothrombinemia (impairment of hemostasis and bleeding)
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| aspirin sensitivity occurs | in person with asthma, nasal polyps, chronic urticaria
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| Tylenol (acetaminophen) adverse effect | renal dysfunction
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| Tylenol (acetaminophen) adverse effect | hepatotoxicity
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| Tylenol (acetaminophen)indications | mild pain and fever
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| Ibuprofen, Naprofen indications | for fever, pain and inflammation caused by trauma, infection, autoimmune disorders, neoplasms, joint degeneration
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| NSAIDs moa | antipyretic effects (inhibit COX isozymes and synthesis of prostaglandins)
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| NSAIDs moa | analgesic effects (inhibit COX isozymes and synthesis of prostaglandins)
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| NSAIDs moa | anti-inflammatory effects (inhibit COX isozymes and synthesis of prostaglandins)
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| Ibuprofen, Naprofen adverse effects | gastric irritation
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| Ibuprofen, Naprofen adverse effects | nausea
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| Ibuprofen, Naprofen adverse effects | dyspepsia
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| Ibuprofen, Naprofen adverse effects | bleeding
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| Ibuprofen, Naprofen adverse effects | peptic ulcer disease
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| indomethacin (Indocin),ketolorac (Toradol) *oral out pt. dosing* | Pain, inflammation, (infant) patent ductus (Indocin)
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| indomethacin (Indocin),ketolorac (Toradol) adverse effects | GI and CNS side effect
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| methotrexate (Rheumatrex); leflunomide (Arava); hydroxychloroquine (Plaquenil) | GI, liver function, diarrhea, alopecia, ocular effects
Category X
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| etanercept (Enbril) (immunomodulators)indication | RA
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| Prednisone (steroid) | treatment of RA
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| Glucocorticoids (steroid) | act more rapidly than other DMARDS
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| Gold salt adverse effect | hemetologic, dermatologic, GI, renal effects.
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| Gold salt adverse effect | flushing, hypotension, tachycardia
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| Gold salt adverse effect | skin rash, stomatitis
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| methotrexate (Rheumatrex) | Autoimmune disorders
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| leflunomide (Arava) | Autoimmune disorders
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| hydroxychloroquine (Plaquenil) | Autoimmune disorders
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| methotrexate (Rheumatrex); leflunomide (Arava); hydroxychloroquine (Plaquenil) | GI, liver function, diarrhea, alopecia, ocular effects
Category X
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| allopurinol (Zyloprim) | GI, dizziness, sore gums, hepatitis
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| probenecid (Benemid) | GI, dizziness, sore gums, hepatitis
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| allopurinol (Zyloprim); probenecid (Benemid) | sore gums
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| allopurinol (Zyloprim); probenecid (Benemid) | hepatitis
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| allopurinol (Zyloprim); probenecid (Benemid) | prevent gout
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| allopurinol (Zyloprim) | prevent gout , overproduce uric acid > 800
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| probenecid (Benemid) | prevent gout , underproduce uric acid < 800
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| indomethacin (Indocin) other NSAIDS colchicine (Colcrys) | treat gout attack
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| colchicine (Colcrys) | treat gout attack
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| indomethacin (Indocin) other NSAIDS colchicine (Colcrys) adverse effects | GI
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| sulfasalazine | treatment of RA
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| Sulfasalazine contraindicated | not for those who are allergic to sulfa compounds
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| methotrexate, leflunomide contraindication | not for pregnant women
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| celecoxib indications | osteoarthritis and RA
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| celecoxib adverse effects | cardiovascular events, diarrhea, dyspepsia, abdominal pain
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| colchicine adverse effects | nausea, vomiting, diarrhea, abdominal cramps
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| indomethacin: | hematological toxicity
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| indomethacin monitored | short-term use, closely monitored
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| Ketorolac special route in NSAIDs | parenteral IV or IM
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| Ketorolac indications | moderate pain postoperative pain associate with dental surgery, migraine headaches, allergic conjunctivitis, ocular inflammation
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| Ketorolac cautions | cause increased risk in renal or hepatic disease
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| Pinoxicam | chronic treatment of RA
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| Advantage of Pinoxicam | 50 hour plasma half-life
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| Nabumetone | prodrug, advantage half-life of 20 hours: allow once daily dosing
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| Diclofenac | treat pain associated with osteoarthritis in joint (topical)
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| Long-term use of NSAIDS cause | renal or hepatic toxicity
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| Nonselective COX inhibitors except Tylenol | cause gastric irritation and bleeding, longterm cause peptic ulcers
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| Acetaminophen weakness | lacks significant anti-inflammatory and antiplatelet activity
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| Celecoxib | the first and only selective COX inhibitor, cause less GI bleeding and peptic ulcers than nonselective COX inhibitors
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| Treatment of RA | NSAIDS- relieve pain and inflammation; and DMARDs - suppress underlying disease and slow joint destruction
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| treatment of osteoporosis | NSAIDs
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