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Pharm test 3

chap 30

Aspirin indications pain, fever, inflammation
Aspirin indications myocardial infarction, stroke, throboembolic disorder
aspirin contraindication not used in children bc it causes Reye's syndrome
aspirin adverse effects gastric irritation
aspirin adverse effects GI bleeding and peptic ulcers
aspirin adverse effects Tinitus (abnormal auditory sensation or buzzing noise)
salicylates adverse effects (aspirin) fever
salicylates adverse effects (aspirin) dehydration
salicylates adverse effects (aspirin) severe metabolic acidosis
excessive doses of aspirin hypoprothrombinemia (impairment of hemostasis and bleeding)
aspirin sensitivity occurs in person with asthma, nasal polyps, chronic urticaria
Tylenol (acetaminophen) adverse effect renal dysfunction
Tylenol (acetaminophen) adverse effect hepatotoxicity
Tylenol (acetaminophen)indications mild pain and fever
Ibuprofen, Naprofen indications for fever, pain and inflammation caused by trauma, infection, autoimmune disorders, neoplasms, joint degeneration
NSAIDs moa antipyretic effects (inhibit COX isozymes and synthesis of prostaglandins)
NSAIDs moa analgesic effects (inhibit COX isozymes and synthesis of prostaglandins)
NSAIDs moa anti-inflammatory effects (inhibit COX isozymes and synthesis of prostaglandins)
Ibuprofen, Naprofen adverse effects gastric irritation
Ibuprofen, Naprofen adverse effects nausea
Ibuprofen, Naprofen adverse effects dyspepsia
Ibuprofen, Naprofen adverse effects bleeding
Ibuprofen, Naprofen adverse effects peptic ulcer disease
indomethacin (Indocin),ketolorac (Toradol) *oral out pt. dosing* Pain, inflammation, (infant) patent ductus (Indocin)
indomethacin (Indocin),ketolorac (Toradol) adverse effects GI and CNS side effect
methotrexate (Rheumatrex); leflunomide (Arava); hydroxychloroquine (Plaquenil) GI, liver function, diarrhea, alopecia, ocular effects Category X
etanercept (Enbril) (immunomodulators)indication RA
Prednisone (steroid) treatment of RA
Glucocorticoids (steroid) act more rapidly than other DMARDS
Gold salt adverse effect hemetologic, dermatologic, GI, renal effects.
Gold salt adverse effect flushing, hypotension, tachycardia
Gold salt adverse effect skin rash, stomatitis
methotrexate (Rheumatrex) Autoimmune disorders
leflunomide (Arava) Autoimmune disorders
hydroxychloroquine (Plaquenil) Autoimmune disorders
methotrexate (Rheumatrex); leflunomide (Arava); hydroxychloroquine (Plaquenil) GI, liver function, diarrhea, alopecia, ocular effects Category X
allopurinol (Zyloprim) GI, dizziness, sore gums, hepatitis
probenecid (Benemid) GI, dizziness, sore gums, hepatitis
allopurinol (Zyloprim); probenecid (Benemid) sore gums
allopurinol (Zyloprim); probenecid (Benemid) hepatitis
allopurinol (Zyloprim); probenecid (Benemid) prevent gout
allopurinol (Zyloprim) prevent gout , overproduce uric acid > 800
probenecid (Benemid) prevent gout , underproduce uric acid < 800
indomethacin (Indocin) other NSAIDS colchicine (Colcrys) treat gout attack
colchicine (Colcrys) treat gout attack
indomethacin (Indocin) other NSAIDS colchicine (Colcrys) adverse effects GI
sulfasalazine treatment of RA
Sulfasalazine contraindicated not for those who are allergic to sulfa compounds
methotrexate, leflunomide contraindication not for pregnant women
celecoxib indications osteoarthritis and RA
celecoxib adverse effects cardiovascular events, diarrhea, dyspepsia, abdominal pain
colchicine adverse effects nausea, vomiting, diarrhea, abdominal cramps
indomethacin: hematological toxicity
indomethacin monitored short-term use, closely monitored
Ketorolac special route in NSAIDs parenteral IV or IM
Ketorolac indications moderate pain postoperative pain associate with dental surgery, migraine headaches, allergic conjunctivitis, ocular inflammation
Ketorolac cautions cause increased risk in renal or hepatic disease
Pinoxicam chronic treatment of RA
Advantage of Pinoxicam 50 hour plasma half-life
Nabumetone prodrug, advantage half-life of 20 hours: allow once daily dosing
Diclofenac treat pain associated with osteoarthritis in joint (topical)
Long-term use of NSAIDS cause renal or hepatic toxicity
Nonselective COX inhibitors except Tylenol cause gastric irritation and bleeding, longterm cause peptic ulcers
Acetaminophen weakness lacks significant anti-inflammatory and antiplatelet activity
Celecoxib the first and only selective COX inhibitor, cause less GI bleeding and peptic ulcers than nonselective COX inhibitors
Treatment of RA NSAIDS- relieve pain and inflammation; and DMARDs - suppress underlying disease and slow joint destruction
treatment of osteoporosis NSAIDs
Created by: prinluu