atherosclerosis

Question	Answer
define atherosclerosis	it is a disease where plaque forms in your arteries
charactersitics	irregular lipid deposits in intima of large/medium arteries - core made out of cholesterol ester - surrounding area - fibrosis and calcification
consequences of atherosclerosis	haemmorage into plaque, narrowing lumen of artery - low blood flow - thrombosis
risk factors	advanced agemalesmokingdiabetes mellitushypertension
risk factors on biochemical level	apo b100,a1,eLCAT;ACATlipoprotein lipase
clinical implications	myocardial infarctionsenile dementiagangrenesstroke
treatment	correct lifestyle, proper diet, drugs which INC HDL and DEC VLDL AND LDL eg. statin - inhibits hmg coa reductase + niacin - decrease vldl formation
T/F -endothelial damage causes the endothelial cells to adhere to LDL	TRUE
T/F- ENDOTHELIAL CELLS + LDL = MACROPHAGES	TRUE
t/f macrophages then consume lipoproteins then form CYTOKINES	FALSE
T/F - macrophages consume lipoproteins and then form foam cells	TRUE
what do foam cells secrete...?	CYTOKINES - for attraction of other macrophagesGROWTH FACTORS - proliferation of smooth muscle cells and fibroblasts
smooth muscle cells then produce ___________and take up __________ to become foam cells	collagen lipids