| Question |
Answer |
| Synthesizes the active tetrahydrofolate (THF) form of folic acid. |
Dihydrofolate reductase |
| Makes a phosphodiester bond between adjacent nucleotides in DNA |
DNA ligase |
| Adds TTAGGG sequences to the ends of chromosomes |
Telomerase |
| Synthesizes deoxy form of nucleotides |
Ribonucleotide reductase |
| Salvages guanine bases to make GMP |
HPRT |
| Catalyzes formation of uric acid |
Xanthine oxidase |
| Has a MG++ cofactor that funcitons to enhance nucleophilic attack by the 3'O of the primer strand |
DNA polymerase |
| Synthesizes an RNA primer to initiate strand synthesis |
Primase |
| Separates the parental strands at the replication fork |
Helicase |
| The biochemical function of cAMP is to activate _______________. |
Protein kinase A |
| An enzyme that digests DNA at specific base sequences. |
|
| Inhibited by malathion |
Acetylcholinesterase |
| Catalyzes the first step in glycolysiss that produces ATP by substrate-level phosphorylation |
Phosphoglycerate kinase |
| Has a high Km for glucose and is acive after a meal |
Glucokinase |
| Covalently links amino acids to their cognate tRNAs |
Aminoacyl-tRNA synthetase |
| Synthesizes cDNA from mRNA |
resverse transcriptase |
| Synthesizes RNA |
RNA polymerase |
| The enzyme primarily responsible for metabolizing alcohol |
Alcohol dehydrogenase |
| Stimulates the activity of phosphofructokinase-1 (PFK-1) |
Fructose 2,6-bisphosphate |
| Catalyzes the production of NADH in glycolysis |
Glyceraldehyde 3-P dehydrogenase (GAPDH) |
| Major regulated step of cholesterol biosynthesis |
HMGCoA reductase |
| Enzyme in eukaryotes that is responsible for mRNA transcription |
|
| Pyruvate carboxylase enzyme requires ___________. |
Biotin |
| Catalyzes the first enzymatic step of steroid synthesis |
Desmolase |
| Pyruvate dehydrogenase requires this as a cofactor. |
thiamin-pyrophosphate |
| Homocysteine methyltransferase requires this as a cofactor |
Cobalamin (B12) |
| Recognizes oriC and recruits the replication proteins |
E. coli DnaA |
| Seals the nick in the phosphodiester backbone |
DNA ligase |
| Introduces negative supercoils in the DNA |
DNA gyrase |
| Synthesizes the bulk of human DNA |
DNA polymerase delta |
| Functions as a "sliding clamp" to make polymerase processive |
PCNA |
| Inhibited by methotrexate |
Dihydrofolate reductase |
| Inhibited by ciprofloxacin |
DNA gyrase |
| Inhibited by azaserine |
Carbamoyl phosphate synthetase II |
| Inhibited by allopurinol |
Xanthine oxidase |
| Inhibited by fluorouracil |
Thymidylate synthase |
| First step in the metabolism of alcohol |
Alcohol dehydrogenase |
| Cleaves the signal peptide from the N-terminus of the growing polypeptide |
Signal peptidase |
| Breaks and reforms S-S bonds between cystein residues in protein folding |
Protein disulfide isomerase (PDI) |
| Shifts proline configuratin between cis and trans isomers |
Peptidyl proline isomerase (PPI) |
| Allows proteins containing proline to adopt the correct configuration |
Peptidyl proline isomerase (PPI) |
| Phosphorylates translational initiation factors (Ifs)leading to the inhibition of translation and reduces proteins entering the ER |
Protein ER Kinase (PERK) |
| A complex of E2/E3 which recognizes and tags a damaged protein for destruction. |
Ubiquitin ligase |
| Enzyme that cleaves fatty acids from phsopholipids. |
Phospholipases |
| Hydrolyzes the ester on the C1 carbon of a phospholipid, giving a free fatty acid and a 1-lysophospholipid |
Phospholipase A1 |
| Hydrolyzes the ester on the C2 carbon of a phospholipid, giving a free fatty acid and a 2-lysophospholipid |
Phospholipase A2 |
| Hydrolyzes the phosphoester bond between the phosphate and the glycerol backbone giving DAG and phosphorylated head group in a phospholipid |
Phospholipase C |
| Hydrolyzes the phosphoester bond between the phosphate and the head group giving PA and free head group in a phospholipid |
Phospholipase D |
| Synthesizes cAMP |
Adenylyl cyclase |
| Breaks down cAMP |
Phosphodiesterase |
HHS Shrek
