| Question |
Answer |
| When does FA synthesis occur? |
When there are more calories ingested than are needed |
| Beginning Product of FA synthesis |
Citrate |
| Citrate converted into what two products in preparation for FA synthesis |
Oxaloacetate and Acetyl CoA |
| Acetyl CoA goes to what |
Malonyl CoA |
| Malonyl CoA |
3 Carbon compound needed for the immediate sgtarting material for FA synthesis |
| What cofactor is needed in all carboxylases? |
biotin |
| Fate of oxaloacetate from citrate lyase reaction |
Oxaloacetate -> Malate -> Pyruvate |
| Location of FA synthesis |
Hepatic cytosol |
| When is FA synthesis active |
Fed state assuming excess calories present |
| FA synthesis Starting material |
NADPH
Malonyl CoA
Acetyl CoA |
| FA Synthesis Products |
NADP+
Palmitate |
| Process of FA synthesis |
Reduction of carbons/oxidation of NADPH (reverse B oxidation) |
| Where do we get NADPH? |
Pentose Phosphate Pathway |
| Fatty Acid Synthase |
large complex of enzymes that binds growing acyl chain and malony CoA in first round. |
| Why is malonyl CoA used rather than acetyl coa? |
allows regulation |
| Fate of new synthesized FA |
activated to fatty acyl CoA for TG synthesis and incorporated into VLDL |
Poultry
