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Biochem-Cosub etc

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Created by: Salma O

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Question	Answer
NADH (& NADPH)	Nicotinamide adenine dinucleotide Precursor: Niacin Defic: Pellagra Role: Redox involving 2-e transfer Enz: Dehydrogenase
FAD	Flavin adenine dinucleotide Precursor: riboflavin B2 Defic: growth retardation Role: redox involving 1- and 2-e transfer Enz: flavoenzymes
CoA	Coenzyme A Precursor: pantothenate B3 Defic: dermatitis in chicks Role: acyl transfer Enz: 100s of enz
TPP	Thiamine Pyrophosphate Precursor: Thiamine B1 Defic: beriberi Role: transfer of 2-C fragment containing carbonyl Enz: some carboxylases
PLP	Pyroxidal Phosphate Precursor: pyroxidal, pyroxine, pyroximine B6 Defic: dermatitis in rats Role: transfer of groups to and from A.A. Enz: transaminase
Biotin	Biotin Precursor: Biotin Defic: dermatitis in humans Role: carboxyl grp transfer & ATP dependent carboxylation Enz: some carboxylases
Tetrahydrofolate	Tetrahydrofolate Precursor: folic acid Defic: anemia, spina befida Role: 1-C transfer Enz: dihydrofolate reductase & others
Cobalamin	Cobalamin Precursor: methylcobalamin, adenosylcobalamin Defic: pernicous anemia Role: intermolecular rearrangement, methyl transfer Enz: methylmalonyl-coA mutase; homocysteine methyltransferase
Lipoamide	Lipoamide Precursor: lipoic acid Defic: NONESSENTIAL Role: acyl transfer Enz:dihydrolipoamide; acyltransferase
Vitamin K	Deficiency: blood clotting disorder Role: carboxylation of Glu Enz: vitamin K-dependent carboxylase
Ubquinone	AKA: Coenzyme Q Role: electron transfer Enz: mitochondrial enzyme
Vitamin A	Role: Vision Solubility: Lipid Deficiency: Night blindness
Vitamin C	Role: Antioxidant Solubility: Water Deficiency: Scurvy
Vitamin D	Role: Gene expression Solubility: Lipid Deficiency: Rickets
Vitamin E	Role: Antioxidant Solubility: Lipid Deficiency: Fragile blood cells