| Question |
Answer |
| Antibiotics, group II -Fungi. Name classes of antibiotics. | 1, Penicillin - natural
2, Penicillin - semisynthetic
3, Cephalosporins - Generation 1-4 |
| Antibiotics, group I -Microorganisms, subgroup -Actinomyces (antibacterial). Name classes of antibiotics. | 1, Aminoglycosides
2, Tetracyclines
3, Chloramphenicol
4, Macrolides
5, Different |
| Antibiotics, group I -Microorganisms, subgroup -Actinomyces (antifungal). Name classes of antibiotics. | 1, Imidazoles
2, Different |
| Antibiotics, group II -Fungi. Side effects. | Allergy, may lead to: anafylactic shock, skin rash, serum sickness, fever, nephritis. |
| Streptomycin -side effect. | Could lead to permanent damage of the auditory nerve -> Hearing loss. |
| Tetracyclines -side effects. | 1, Antibiosis -> Candidosis
2, Hepatic- and kidney damage
3, Brown discoloration of teeth (in children) |
| Chloramphenicol -side effects. | Bone marrow suppression, leading to Aplastic anemia. |
| Name antibiotics that are very toxic to toxic. | Very toxic: Vancomycin.
Toxic products:
1, Nystatin (antifungal)
2, Antitumoral a/b (Actinomycin, Mitomycin, Dactinomycin)
3, Polymixin B, Gramicidin (antibacterial) |
| Generic name of: Penicillin -natural. | 1, Penicillin G
2, Penicillin V |
| Generic name of: Penicillin -semisynthetic | 1, Ampicillin
2, Methicillin
3, Carbenicillin
4, Oxacillin |
| Generic name of: Cephalosporins G1 | 1, Cephalotin
2, Cephazolin
3, Cephapirin |
| Generic name of: Cephalosporins G2 | 1, Cefamandole
2, Cefuroxime |
| Generic name of: Cephalosporins G3 and G4 | 1, Cefotaxime -G3
2, Ceftriaxone -G3
1, Cefpirome -G4 |
| Generic name of: Aminoglycosides | 1, Streptomycin
2, Kanamycin
3, Neomycin
4, Gentamycin |
| Generic name of: Tetracyclines | 1, Oxytetracycline
2, Chlortetracycline
3, Tetracycline
4, Doxycycline
5, Minocycline |
| Generic name of: Macrolides | 1, Erythromycin
2, Azithromycin
3, Clarithriomycin |
| Generic name of: Imidazoles | 1, Clotrimazole
2, Miconazole
3, Ketoconazole |
| Generic name of: Different
(actinomyces-antibacterial) | 1, Lincomycin
2, Clindamycin
3, VANCOMYCIN
4, Rifamycin
5, Rifampin |
| Generic name of: Different
(actinomyces-antifungal) | 1, Nystatin
2, Amphotericin B |
| Generic name of: Different
(actinomyces-antitumoral) | 1, Actinomycin
2, Mitomycin
3, Dactinomycin |
| Generic name of: Different
(Bacteria-antibacterial) | 1, Polymixin B
2, Bacitracin
3, Gramicinin
4, Mupirocin
5, Colistins |
| Generic name of: Different
(human/animal-antibacterial) | 1, Lysozome
2, Erythrin
3, Spermine |
| Generic name of: Different
(plant-antibacterial) | 1, Phytoncides |
| Target and mechanism of action for: Penicillin -natural | Narrow spectrum
Gr+
Gr-
Spirochetes
Inhibit CW synthesis |
| Target and mechanism of action for: Penicillin -semisynthetic | Broad spectrum
Inhibit CW synthesis |
| Target and mechanism of action for: Cephalosporins G1 | Good Gr+
Modest Gr-
Inhibit CW synthesis |
| Target and mechanism of action for: Cephalosporins G2 | Good Gr+
Better Gr-
Inhibit CW synthesis |
| Target and mechanism of action for: Cephalosporins G3 | Good Gr-
Modest Gr+
Ps.aeruginosa
Inhibit CW synthesis |
| Target and mechanism of action for: Cephalosporins G4 | Good Gr-
Ps.aeruginosa
Inhibit CW synthesis |
| Target and mechanism of action for: Aminoglycosides | Enteric Gr-
Ps.aeruginosa
Bactericidal effect, inhibit protein synthesis |
| Target and mechanism of action for: Tetracyclines | Very broad spectrum
Gr+
Gr-
Rickettsias and Chlamydias
Bacteriostatic effect |
| Target and mechanism of action for: Chloramphenicol | Broad specturm
Gr+
Gr-
Rickettsias, Chlamydias and anaerobes
Bacteriostatic effect, inhibit protein synthesis |
| Target and mechanism of action for: Macrolides | Narrow spectrum
Gr+
Gr-
Legionella, C.diphteriae, Mycoplasmas, Chlamydias
Bacteriostatic effect, inhibit protein synthesis |
| Target and mechanism of action for: VANCOMYCIN | Very narrow spectrum against multiresistant bacteria.
Bactericidal effect, inhibit CW synthesis |
| Target and mechanism of action for: Rifamycin and Riampin | Narrow spectrum
Gr+ (even multiresistant)
M.tuberculosis
Bactericidal effect, inhibit synthesis of mRNA |
| Target and mechanism of action for: Imidazoles | Broad spectrum antifungals
Candida, dermatophytes and systemic fungal infections.
Interfere w/ sterole synthesis which inhibits cell membrane synthesis, plus anitmetabolic effects. |
| Target and mechanism of action for: Polymixin B | Topical use in wound infections of Gr-
Bactericidal effect, inhibit cell membrane synthesis. |
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