| Question |
Answer |
| When does FA synthesis occur? | When there are more calories ingested than are needed |
| Beginning Product of FA synthesis | Citrate |
| Citrate converted into what two products in preparation for FA synthesis | Oxaloacetate and Acetyl CoA |
| Acetyl CoA goes to what | Malonyl CoA |
| Malonyl CoA | 3 Carbon compound needed for the immediate sgtarting material for FA synthesis |
| What cofactor is needed in all carboxylases? | biotin |
| Fate of oxaloacetate from citrate lyase reaction | Oxaloacetate -> Malate -> Pyruvate |
| Location of FA synthesis | Hepatic cytosol |
| When is FA synthesis active | Fed state assuming excess calories present |
| FA synthesis Starting material | NADPH
Malonyl CoA
Acetyl CoA |
| FA Synthesis Products | NADP+
Palmitate |
| Process of FA synthesis | Reduction of carbons/oxidation of NADPH (reverse B oxidation) |
| Where do we get NADPH? | Pentose Phosphate Pathway |
| Fatty Acid Synthase | large complex of enzymes that binds growing acyl chain and malony CoA in first round. |
| Why is malonyl CoA used rather than acetyl coa? | allows regulation |
| Fate of new synthesized FA | activated to fatty acyl CoA for TG synthesis and incorporated into VLDL |
CADD 2 Honors
