Question | Answer |
helper proteins that overcome kinetic barriers are called? | heat shock proteins (isomerases) |
heat shock proteins are also called what? | chaperonins |
what proteins are involved in folding? | prolyl cis/trans isomerases, protein disulfide isomerases, and disulfide reductases |
what molecule cleaves peptide bonds in front of aromatic amino acids? | chymotrypsin |
to degrade proteins, what molecule is added? | ubiquitin |
what is the ligand that binds to proteins and causes ubiquitin to attach? | E3 |
glycation aggregates are called what? | advanced glycation end products (AGES) |
HbA1C is a measure of what? | hemoglobin glycosylation |
what are two major aberrations of protein folding? | prion's disease and alzheimer's disease |
is an isoform the same or different gene? what about a mutation? | different, same |
ck is important in regenerating what? | atp |
what happens to intracellular ck when it is elevated? | it diffuses out of the cell |
HbF has increased oxygen affinity why? | decreased 2,3-BPG binding |
HbF gamma chains have what AA instead of serine? | histidine |
collagens have many ____ which lead to diseases? | polymorphisms |
what are the 2 human prion diseases? | creutzfeldt-jakob disease and variant cjd |
protein misfolding can cause the _____ that lead to alzheimer's disease? | plaques |