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Patho Ch 3 Pg. 70-75

What does chemical injury begin with? a biochemical interaction between a toxic substance and the cell's plasma membrane.
What are the 2 chemically induced causes of membrane distruction? 1) direct toxicity 2)formation of reactive free radicals and lipid peroxidation.
What do lipid-acceptor proteins bind with? triglycerides to form lipoproteins
What are some methods contributing to inactivation or termination of Free radicals? anitoxidants and enzymes
What are the common sources of lead exposure? environmental, occupational, hobbies, cosmetics
What is lead? a heavy metal that persists in the environment.
What organ systems are primarily affected by lead ingestion? nervous system, hematopoietic system (tissues that produce blood cells), and the kidneys.
What makes carbon monoxide (CO) so dangerous? it is odorless, colorless and undetectible hass unless it is mixed with a visible or odorous pollutant.
What are the symptoms of CO poisoning? headache, giddiness, tinnitus, nausea, weakness and vomiting.
Who is at risk for CO exposure? Those who: 1) Breath air polluted by gasoline engines or defective furnaces 2) work in occupations such as coal mining, fire fighting, welding or engine repair. 3)smoke cigarettes, cigars or pipes.
What is the primary choice among mood altering drugs available in the US? ethanol or alchohol
What are the most serious concequences of alcohol abuse? Liver and nutritional disorders
What are the nutritional defeciencies related to alcohol abuse? magnesium, vitamin b6, thiamine and phosphorus and also effects folate metabolism
How is alcohol metabolized in the blood? 1) Hepatic alcohol dehydrogenase (ADH), an enzyme of the cytosol that catalyzes the conversion of ethanol to acetaldehyde.
What does acute alcoholism affect? CNS but may induce reversible hepatic and gastric changes.
What does chronic alcoholism cause? structural alterations in practically all organs and tissues in the body.
Growth retardation, facial anomalies, cognitive impairment, and ocular malformations are characteristics of what disorder? Fetal alcohol syndrome
What is a cause of hepatic injury, terminating in cirrhosis? alcohol
What are the 3 main sources of mercury exposure? 1) fish consumption 2) dental amalgams 3) vaccines
What are the systemic effects of Marijuana? alterations of sensory perceptions, cognitive and psychomotor impairment, smoking 3-4 per day is equivelant to 20 cigarettes. fertility and sperm problems.
What are the systemic effects of METH? irrability, violent behavior, anxiety, excitement, halllucenations and paranoia.
What are the systemic effects of cocaine and crack? hypertension, tachycardia and vasoconstriction
What are the systemic effects of heroin? highly addictive, withdrawl causes intense fear
Created by: westnm