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Session 3 Pharm- 10
Pharm -10- protein synthesis inhibitors 2
| Question | Answer |
|---|---|
| What type of drug is Gemifloxacin (Factive) | Fluoroquinolone (DNA synthesis inhibitor) |
| What type of drug is Moxifloxacin (Avelox) | Fluoroquinolone (DNA synthesis inhibitor) |
| What type of drug is Levofloxacin (Levaquin) | Fluoroquinolone (DNA synthesis inhibitor) |
| What type of drug is Ciprofloxacin (Cipro) | Fluoroquinolone (DNA synthesis inhibitor) |
| What type of drug is Ofloxacin (Floxin) | Fluoroquinolone (DNA synthesis inhibitor) |
| What type of drug is Lomefloxacin (Maxaquin) | Fluoroquinolone (DNA synthesis inhibitor) |
| What type of drug is Norfloxacin (Noroxin) | Fluoroquinolone (DNA synthesis inhibitor) |
| What type of bacteria does Ciprofloxacin cover | covers lesser and great gram negatives, 1 of 2 fluoroquinolones for pseudomonas (other is levofloxacin) and covers atypicals |
| What type of coverage do you get from levofloxacin | covers gram + (not MRSA), enterococcus faecalis and pseudomonas, some anaerobes, and the atypicals |
| What region of the body is Cipro generally associated with tx | below the waist good for UTIs, STDs |
| What region of the body are the 3rd generation fluoroquinolones associated with tx | above the waist or respiratory FQs |
| What two fluoroquinolones would you not prescribe for UTIs | moxifloxacin and Gemifloxacin |
| Which Fluoroquinolone is prescribed for tx of anthrax | Ciprofloxacin |
| Do you have to adjust dosage in renally impaired pt when giving fluoroquinolones | yes |
| What education do you have to give pt about drug interactions when taking fluoroquinolones | forms complexes with metallic ions so avoid taking them with antacids, multivitamins or food that has metals in it |
| What are the major s/e of the fluoroquinolones | Hypo/Hyperglycemia, CNS effects, cartilage damage (avoid in pregnancy), QTc prolongation, tendon rupture (elderly), Rash |
| What type of drug is Bactrim | sulfamethoxazole and trimethoprim combo |
| What is the place in therapy for Bactrim | acute uncomplicated cystitis (first line), Pneumocystis jiroveci (PCP and PJP pneumonia), Also may be useful for CA and HA MRSA |
| What are some of the major s/e of using Bactrim | urticaria to anaphylaxis rxn, Rash can be mild to fatal SJS. N/V/D, myelosuppression, Hyperkalemia, increase in Scr |
| What are the three regimens recommended for latent TB infection | Isoniazid x9 months or 6 months or rifampin x4 months |
| What is the tx protocol for active TB | 2 months using 4 drugs then 4-7months with 2 drugs (combinations can be varied and complicated depending on resistance) |
| What type of drug is isoniazid (INH) | major first line drug for tx of TB |
| What type of drug is Rifampin (RIF) | major first line drug for tx of TB |
| What type of drug is Pyrazinamide (PZA) | major first line drug for tx of TB |
| What type of drug is Ethambutol (EMB) | major first line drug for tx of TB |
| What two drugs are special circumstance first line drugs for TB tx | rifabutin and rifapentine |
| When should you avoid giving Isoniazid (INH) | it is metabolized by liver avoid giving in active liver disease |
| What are the major s/e of Isoniazid (INH) | Clinical hepatitis and fatal hepatitis, Peripheral Neuropathy |
| What are the major s/e of rifampin | hepatotoxicity, thrombocytopenia, flu-like syndrome, rash, orange discoloration of bodily fluids (tell pt may stain cloths and contact lenses) |
| What are the major s/e of pyrazinamide | hepatotoxicity, GI symptoms, Arthralgias/ gouty arthritis |
| when is pyrazinamide contraindicated | contraindicated in pt suffering from gout |
| What are the major s/e of Ethambutol | Retrobulbar neuritis (decreases visual abilities damage can be permanent), |
| Which of the TB first line tx is not hepatotoxic | only one is ethambutol |
| Which fluoroquinolones can also be used to tx active TB | levofloxacin, and Moxifloxacin |
| Which aminoglycosides are also useful in tx of active TB | streptomycin (used to be first-line) Amikacin/Kanamycin, Capreomycin |
| What is the almost exclusive use of cycloserine | tx of active TB |
| What are the major s/e of cycloserine | CNS effects |
| What is Ethionamide used for | tx of active TB |
| what are the major s/e of Ethionamide | GI symptoms, Hepatotoxicity, Neurotoxicity |
| What are the major s/e of P-Aminosalicylic acid (PAS) | hypothyroidism, GI symptoms, hepatotoxicity |
Created by:
smaxsmith
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