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ANS receptors

PPT 3 - Cholinergic/Adrenergic/Dopamine receptors

TermDefinition
Cholinergic receptors (PNS receptors) 1)Muscarinic (GPCRs) 2)Nicotinic (ion channels)
Muscarinic receptors (G-qiqiq) M1 (Gq), M2 (Gi), M3 (Gq), M4 (Gi), M5 (Gq)
M1 (Gq) location Presynaptic nerve terminals, CNS
M2 (Gi) location HEART, presynaptic nerve terminals, CNS
M3 (Gq) location LUNGS, blood vessels, CNS, eye, GI, glands, bladder
M4 (Gi) & M5 (Gq) location CNS
Nicotinic receptors (ion channels) Nn & Nm receptors
Nn location ANS ganglia, presynaptic nerve terminals
Nm location skeletal muscle NMJ
response of effector tissue (Heart) to M2 receptor decreased contractility, HR, conduction velocity
response of effector tissues to M3 receptor BVs-relax (dilate) Lung bronchi-contract Gland of lungs-inc secretion Eye-contracts (miosis), inc. curvature (more oval) Salivary & Sweat glands-inc secretion GI tract-inc motility & secretion Bladder wall-contract Bladder external sphincter-relax
SNS receptors Adrenergic receptors (a1,a2,b1,b2,b3) Dopaminergic receptors (D1,D2)
Adrenergic receptors (G-q,i,s,s,s) 1) alpha 1,2 2) beta 1,2,3
Dopaminergic receptors (G-s,i) D1 (Gs), D2 (Gi)
a1 (Gq) location smooth muscles, glands
a2 (Gi) location CNS, presynaptic nerve terminals
b1 (Gs) location HEART, CNS
b2 (Gs) location LUNGS, smooth muscles, presynaptic nerve terminals, heart
b3 (Gs) location BLADDER wall, fat cells, endothelial cells
D1 (Gs) location and response BVs (renal, coronary, cerebral) -relax (dilate)
D2 (Gi) location and response Pituitary -dec prolactin secretion
response of effector tissues to a1 receptor (vasoconstriction, contraction) BVs-vasoconstriction eye-contract dilator fibers (Mydriasis) salivary & sweat glands-inc secretion (palms only) bladder internal sphincter-contract (pee less) uterus (near term)-contract penis-ejaculation skin pilomotor muscle-contract (erect)
response of effector tissues to a2 receptor (vasoconstriction, decrease) presynaptic nerve terminal-autoreceptor, dec NE release BVs-autoreceptor, vasoconstriction eye ciliary body-dec synthesis of aqueous humor GI-dec motility CNS-dec SNS activity & Activates post-synaptic a2a receptors (dec prefrontal cortex firing)
response of effector tissues to b1 receptor (increase) Heart-inc contractility, HR, conduction velocity Kidney-inc secretion of renin
response of effector tissues to b2 receptor (relax, increase) LUNGS-bronchodilation BVs-relax (dilate) Bladder wall-relax eye ciliary body-inc aqueous humor, relax ciliary m. uterus (non-pregnant)-relax skeletal muscle-inc contractility, inc glycogenolysis & K+ uptake heart-minor contractility
response of effector tissues to b3 receptor (relax) bladder wall (detrusor m.) - relax
a1, b2 - metabolic effect on liver Glycogenolysis
b2 - metabolic effect on skeletal muscles Glycogenolysis, inc K+ uptake
b1,b2,b3 - metabolic effect on adipose tissue Lipolysis
a2 - metabolic effect on adipose tissue Decrease lipolysis
b2 - metabolic effect on pancreas Glucagon secretion, insulin secretion (minor)
a2 - metabolic effect on pancreas Decrease insulin secretion
Mydriasis (pupil dilation) a1 receptors activation contract RADIAL (dilator) fibers of iris (SNS effect)
Miosis (pupil shrinkage) M3 receptor activation contract SPHINCTER (circular) fibers of iris (PNS effect)
a2 receptors - effect on ciliary body epithelium decrease secretion of aqueous humor
b2 receptors - effect on ciliary body epithelium increases secretion of aqueous humor
which receptors mediate FAR vision? (SNS) b2 receptors
which receptors mediate NEAR vision? (PNS) M3 receptors
Created by: valenciachris112
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