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bios ch. 18
Term | Definition |
---|---|
phase where cell not dividing or in cell cycle | G0 |
cell cycle phases | G1, S, G2, M |
checkpoint | where cell cycling can be checked and paused |
cyclin dependent kinase only active in the presence of | cyclin |
M-cyclin | necessary to activate CdK |
CdK inhibitors | no cycling even if cyclin-CdK -p |
what starts cell cycling | growth factors |
Rb is a | tumor supressor |
p21 inhibits | S-cyclin-CdK |
p53 | tumor supressor |
M-cyclin/CdK triggers changes in | prophase |
prophase | chromatin condenses and nuclear envelope is broken |
cohesions | keeps sister chromatids together |
when all kinetochores are bound to MTs and pulled equally: | anaphase promoting complex/C becomes active |
anaphase promoting complex/C (APC/C) is a | ubiquitin ligase |
dyneins pull MTOC | towards (chromosomes or plasma membrane) |
kinesins push MTOC | away (MTOCs separate) |
cytokinesis | split one cell into 2 |
anaphase | chromosome separation |
APC/C ubiquinates | M-cyclin and securin |
once ubiquinated, separase | cleaves cohesion |