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PC_Macrolides
Pharmacology
Question | Answer |
---|---|
MOA | Inhibit protein synthesis by combiningwith ribosomes |
CI | Pulmonary infections, chlamydia, Haemophilus influenza |
AR | May cause gastrointestinal distress |
SC | Patient should take macrolides with food. Clarithomycin may leave a metallic taste in one's mouth. The first dose of azithromycin is a loading dose, which is twice the normal daily dose. |
RC | Reconstituted azithromycin injection is good for 24 hours when refrigerated; oral suspension will last 10 days if refrigerated. Clarithromycin does not need to be refrigerated but will expire in 14 days. Erythromycin for IV must be used within 8 hours |