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Path- Eponyms T4-3

Lutz CA

CNS Lymphoma AIDS
Carribean, Japan HTLV
Nasopharyngeal T cell lymphoma EBV Asia, South America
B cell lymphoma Hep C
MALT of stomach H. Pylori
cutaneous MALT Borrelia burgdorferi
t11;14 Mantle Cell Lphoma BCL-1, prevent apoptosis
t14;18 Follicular Center Cell Lphoma BCL-2, upreg prolif
stage determined CA Hodgkins
CD 20+, 45+ Lcyte Predominance Hodgkins
Females, mediastinum involved Nodular sclerosis, 20-70% Hodgkins
CD 5, 20, 23 SLL/CLL
CD 5, 20 Mantle cell
CD 10, 20, 23 Follicular cell
CD 20, 23 Marginal zone, malt
t11;18 Marginal zone, malt
lethal midline granuloma, Asia Central America NK/T cell Lphoma; EBV CD56+
erythroderma+ blood involvement Sezary Sx
cerebriform nuclei, Pautrier uabscess Mycosis fungoides
aggressive, children, mediastinum, CD3, Tdt Lblastic Lphoma
CD 30+, ALK+, t2;5 Anaplastic large T cell Lphoma
<10% plasma cell, no lytic bone lesion MGUS
m/c 1* bone CA, M protein, Bence-Jones, OAF Mult Myeloma
B-pleated sheet, Congo red stain Amyloid
Ig light chain AL
SAA acute phase reactant AA
m/c systemic amyloid, <60% PC, free light chain AL
arthritis, RA, Chronic sepsis, slower>AL AA
high SAA, elderly, ESRD, Crohn's, Chronic sepsis poor prognosis
TB, mycobacteria, fungal, sarcoid granuloma
monoclonal CA causing virus
polyclonal DNA methylation
CA causing viruses HPV, EBV, HTLV
predicts clinical outcome well stage
wt of detectable CA 1g
cell # of detectable CA 1 billion, 30 cell division
cell # to kill the pt 1 kg, 1000 billion cell
CD 133+, blast crisis CA stem cell
size of blood supply 1mm req bl supply
dominant negative mutation p53 tumor suppressor, one loss=CA
sis protooncogene PDGF
autocrine cell growth w/ PDGF astrocytoma, osteosarcoma
HER2/neu EGF-R
breast CA, ovarian CA HER2/neu R
ineffective EGF-R inhibitor KRAS mutation
ret oncogene thyroid carcinoma, MEN
loss of inhibitory abl domain abl-bcr, CML
signal transduction in 15-20% of CA ras
codon 12 13 ras-GTP always active
GTPase Activating Protein, tumor suppressor NF-1, degrade GTP->GDP
melanoma, NF NF-1
lung CA, downregulate ras LET7microRNA
transcription factors C-myc, L-myc, N-myc
tumor suppressor, cell cycle regulator Rb
bind E2F transcription factor Rb
suppress cell cycle Rb-E2F recruit HDACs
inc cyclin inc prolif thru CDK->Rb-po4 + E2F
Rb inactivated in retinoblastoma, osteosarcoma
Rb inactivated by HPV
Knudson's hypothesis 1 defective allele inherited, 1 more for CA
cyclin D1 activation bcl-1 Mantle cell, t11;14
ATM ataxia telangectasia
DNA repair proteins recruited by RAP80 BRCA1, ABRA1
NER UV light Xeroderma Pigmentosum
BER smoking, reactive O2, bases go 1st
MMR MSH2, MLH1; hi MSI-> Lynch Sx
HR BRCA1, BRCA2 in breast, ovarian CA
prevent rasGTP-x->rasGDP pt mut in codon 12 13 and NF-1
Ig heavy chain next to C-myc t8;14 Burkitt Lphoma
acetylation of histone H3 H4 activation
histone H3 Lys 4 methylation active transcription
histone H3 Lys 9 methylation inactive transcription
ALL1/MLL Lys 4 methylator in ALL AML
Molec Mech #1 APC/MUTYH loss, Kras mut, p53 loss
Molec Mech #1 adenomatous polyp, M>F, Lt>rt, 60% spor, FAP
molec Mech #2 CIMP, BRAF1 mut, hi MSI, methylated promoter, MGMT loss
molec Mech #2 serrated polyp, F>M, Rt>lt, 20% spor
molec mech #3 mut MSH2, 6, MLH1, PMS2, HNPCC/Lynch sx
FAP APC loss benign polyp, 42 yo, Tx- proctolectomy
Lynch Sx init adenoma, 48yo, Tx- colonoscopy
Apoptos Extrinsic pathway TNF, Fas bind Init caspases-> Effector caspase
Apoptos Intrinsic pathway Bak, Bax, Bim
anti- apop Bcl-2 Bcl-x
Bcl-> cytC-> Apaf-1-> Init caspase-> effector caspase
telomere sequence TTAGGG
melanoma neural crest origin, Slug TF.
sarcomas [bone] metastasize to lung
lung carcinoma metastasize to brain
colorectal CA metastasize to liver
Created by: mcafej02