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Designer Drugs
Tox Final
Question | Answer |
---|---|
synthetic cannabinoids | compounds similar in structure to and/or mimic effects of THC |
synthetic cathinones | amphetamine-like compounds that have stimulant and/or hallucinogenic effects |
Federal analog laws | similar in chemical structure and/or effects to schedule I or II drugs are banned |
AL state analog laws | same a federal, but broadened to include drugs with stimulant, depressant, or hallucinogenic effects and drugs which bind to cannabinoid receptors and have the ability to produce an effect |
What are the effects/uses of cannabinoid antagonists? | decrease food intake; initially showed some promise as treatment for obesity |
JWH | J. W. Huffman, first to produce synthetic cannabinoids JWH compounds have an indole group with and N-modification |
HU | Hebrew University, dibenzopyran structures, 100-800x stronger binding to CB1, resembles classic THC structure |
CP | Pfizer, cyclohexyphenol, 45x stronger than THC, binds CB1 |
WIN | Sterling Winthrop, aminoalkylindoles |
Where are CB1 receptors located? | Mainly in the brain. Also in CNS, muscle, lungs, liver, kidney |
What effects are produced when CB1 is activated? | euphoria, relaxation, cognitive impairment |
Where are CB2 receptors located? | immune system. Effects are not known at this time |
Why are synthetic cannabinoids toxic but THC isn't? | THC is a partial agonist, but synthetics are full agonists |
From what plant are cathinones derived? | Khat |
What are the medical uses for bupropion? | depression, smoking cessation |
When is the typical onset of effects for synthetic cathinones? | 15-45 minutes |
What is the mechanism of action for synthetic cathinones? | inhibit reuptake of dopamine, serotonin, and norepinephrine, block membrane catecholamine transporters, incrase pre-syntptic release |
What are the intended effects of synthetic cathinones? | euphoria, increased alertness, energy, sexual arousal |
What are the side effects of synthetic cathinones? | severe agitation, rapid heart rate, high blood pressure, paranoia, hallucinations, delusions, extreme agression |
What is the result of mixing alcohol with energy drinks? | get drunk faster and reduce sedative effects of alcohol |
What is the half life of phenazepam? | 15-60 hours |
How is phenazepam metabolized? | 3-OH-phenazepam via CYP3A |
What are some effects of phenazepam? | dizziness, incordination, asthenia, somnolence |
What is commonly seen with phenazepam? | marijuana, synthetic cannabinoids, and bath salts |