Busy. Please wait.

Forgot Password?

Don't have an account?  Sign up 

show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.

By signing up, I agree to StudyStack's Terms of Service and Privacy Policy.

Already a StudyStack user? Log In

Reset Password
Enter the email address associated with your account, and we'll email you a link to reset your password.

Remove ads
Don't know (0)
Know (0)
remaining cards (0)
To flip the current card, click it or press the Spacebar key.  To move the current card to one of the three colored boxes, click on the box.  You may also press the UP ARROW key to move the card to the "Know" box, the DOWN ARROW key to move the card to the "Don't know" box, or the RIGHT ARROW key to move the card to the Remaining box.  You may also click on the card displayed in any of the three boxes to bring that card back to the center.

Pass complete!

"Know" box contains:
Time elapsed:
restart all cards

Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

MICABI - Exam 1

Macrolides - erythromycin

erythromycin - general chemistry basic, easily hydrolyzed as free base, destroyed by stomach acids
oral forms of erythromycin (4) Erythromycin free base - enteric coated; Erythromycin estolate, Erythromycin stearate, Erythromycin ethyl succinate
IV forms of erythromycin (2) Erythromycin lactobionate; Erythromycin gluceptate (glucoheptonate)
IM form of erythromycin (1) Erthromycin ethyl succinate
Erythromycin mechanism of action Inhibition of protein synthesis; binds to domain V of 50S subunit of prokaryotic ribosome and inhibits translocation (bacterostatic - not used for severe infections)
four mechanisms of erythromycin resistance in bacteria 1) plasmid mediated methylation of ribosome; 2) altered permeability; 3) mutations in Domain 5 of the 23s rRNA; 4)and mutations of 2 different ribosomal proteins(phenotypes-ML and MSB)
MLSB bacteria are resistant to which classes of antibiotics macrolides, lincosamides, and streptogramin B
MLSB phenotype is conferred to bacteria how by methylation of a single adenine in the bacterial 50s ribosome that binds to erythryomycin (erm)
two forms of MLSB resistance inducible (iMLSB) or constitutive (cMLSB)
primary spectrum of erythromycin gram positive cocci (strep & staph) and atypicals like mycoplasma pneumoniae; Legionella pneumophilia; treponema pallidum; Chlamydia and Some Mycobacteria (TB)
absorption of erythromycin poor oral absorption, must be taken on empty stomach
erythromycin Distribution/Metabolism/Excretion Widely distributed to soft tissues, skin, etc. Crosses poorly into CSF; concentrated in liver/excreted in bile; P450 drug interactions
erythromycin adverse events GI upset from oral administration due to the irritation and stimulation of gastric motility; Cholestatic hepatitis, jaundice (rare - estolate prep); Ototoxicity (rare, v. high dose)
erythromycin - clinical uses Mycoplasma pneumonia; Acne (inflammatory) – topical or oral; Chlamydia (GU or eye); 2ndary to B-lactams for respiratory and soft-tissue infections caused by gram-positive cocci; Syphilis (2nd choice after penicllin); w/neomycin colorectal; ot med (w/sulf
Created by: Krafty