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Clin Med
Term | Definition |
---|---|
Cell | smallest unit capable of sustaining life Chemical components organized in a self-sustaining manner |
Nervous | action potentials & membrane pumps |
Muscular | generating tension (sarcomere) |
Tissue | groups of cells w/ a shared purpose |
Connective | Support & connection (elastin) |
Epithelial | exchange btwn cell & surroundings (secretory glands) |
Organ | 2 or more types of tissues organized for fxn(s) |
Orginism | manifestation of the interaction of bodily systems |
Cytoskeleton | Cell shape |
Microtubules | Maintain patency (openness) Ex. nerve axon Allow asymmetric cell shape. |
3 Roles of Microtubules | 1. Transport of secretory vesicles (axon flow) by mc motors. 2. Give shape to cilia & flagella 3. Mitotic spindles. |
2 Mc Motors | 1. Kinesin 2. Dynein |
Dynein | Distal to prox Ex. Debris & waste for removal to cell body. |
Kinesin | Prox to distal |
Microfilaments | Smallest Most cmn: myosin & actin |
2 fxn's of Microfilaments: | 1. Contractile mechs 2. Enhance cell structure & stability |
Actin | Exs. 1. Contractile ring during cytokinesis 2. Myofibroblasts- wound closure |
Intermediate-filaments | Stability & Resistance to ext applied stress. |
2 most important Intermed-filaments | 1. Neurofilaments 2. Keratin 3. desmosomes |
Epidermolysis bullosa | skin |
Amyotrophic lateral sclerosis | motor neuron degeneration |
Endoplasmic Reticular | Fxn: to make protein & lipid Rough ER (& ribosomes): synth proteins for secretion or int membr support; synth lipids for new membranes. |
Smooth ER | purpose: packing & discharging from ER |
Golgi comples | Fxn: further processing releases secretory vesicles through exocytosis |
2 important steps that occur in the Golgi Complex | 1. Raw mats processed into finished prod 2. Sorting finished prods to final destination |
Lysosomes | Sacs of hydrolytic enzymes Clean up crew digest old organelles & their wastes, prods, etc... Phagocytosis |
3 types of endocytosis: | 1. pinocytosis 2. phagocytosis 3. Receptor-mediated endocytosis |
Phagocytosis | lg particles pseudopods extend from membr to engulf particle |
Receptor-mediated endocytosis | binding signals internalization of membr |
Peroxisomes | Oxidative enzymes & catalase oxidize waste prods |
Vaults | mRNA to site of protein synth neg role in cancer- drug resistance |
3 membr components: | 1. Cholesterol 2. Membr proteins 3.CHO's |
Fluid-mosaic model | permits shape changes |
Channel Membrane Proteins | membrane spanning; water-sol subs only; ions; small |
Carrier Molecule | trans specific subs unable to pass independently through channel proteins; lg; vs. conc grad or not. |
Docking marker acceptors | dock & lock incoming secretory vesicles |
Membr bound enzymes | |
Receptor proteins | bind mc's for cell fxn; binding triggers event inside cell |
Cell adhesion proteins | hold proteins of tissues together |
extra-cellular matrix (ECM) | biological glue; interstitial fluid; permits diffusion btwn blood & cells |
3 Major Proteins (in CHO-based gel): | 1. Collagen 2. Elastin 3. Fibronectin offer structural connection from cell to cell |
Collagen | resists longitudinal stress (ex. skin); tensile strength resists stress |
Fibronectin | Connector protein (CAM) |
3 specialized cell jxn's beyond the ECM: | 1. Desmosomes 2. Tight jxn's 3. Gap jxn's |
Desmosomes | designed to hold cells together very strongly; spot rivots; in tissues subjected to stress |
Gap jxns | tunnels that facilitate passage or rapid comm btwn cells |
Mobilization | breakdwn of lipid at storage site into FFA's; stim'd by hormone sensitive lipase- release from storage for mobilization; HAL is inhibited by high insulin or high blood glucose levels |
Uptake (into cell) | Specific receptors for FFA on the sacrolemma (Fatty acid binding protein- FABP) |
Activation | occurs in cytoplasm; raises energy level of FA to prep for entry to metab; costs 2 ATP |
Translocation | transfer across mitochondrial membr by carnitine |