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Zidovudine Nucleoside Reverse Transcriptase Can be used in pregnancy-given to mom then kid for 3 weeks Not compatible with stavudine
Didanosine Nucleoside Reverse Transcriptase Peripheral Neuropathy, pancreatitis
Lamivudine Nucleoside Reverse Transcriptase Treats Hepatitis B =Hep B flare when withdrawn
Abacavir Nucleoside Reverse Transcriptase Sever hypersensitivity reactions
Emtricitabine Nucleoside Reverse Transcriptase Lamivudine Analog Treats Hepatitis B Cause Hyperpigmentation of Palms/Soles Best tolerated
Tenofovir Nucleotide Reverse Transcriptase phosphorylated to nucleoside Treats Hep B No p450 action
Nevirapine Non-Nucleoside Reverse Transcriptase Can Cause Rash
Evfavirenz Non-Nucleoside Reverse Transcriptase P450 Metabolism Neural tube defects Long half life
Ritonavir Protease Inhibitors P450
Indinavir Protease Inhibitors P450 Nephrolithiasis, skin issues
Nelfinavir Protease Inhibitors P450 most common used
Atazanavir Protease Inhibitors P450 abnormal fat distribution
Albendazole Antihelminthic Inhibits Microtubule Glucose Transport 1st line all the time
Pyrantel Antihelminthic Activates cholinergics, depolarizing neuromuscular blockade. OTC
Praziquantel Antihelminthic-Cestodes Causes Spastic contraction then paralysis due to calcium influx disloges jaw in cestodes. Give Mg 15-30g 2 hrs post treatment
Metronidazole Antiprotozoal Symptomatic, Not for use as a contact or luminal Amebicide Inhibits DNA synthesis
Iodoquinol Antiprotozoal Not absorbed, used for luminal Combined with metronidazole Unknown MOA
Paromomycin Antiprotozoal Aminoglycoside, inhibits protein synthesis binds 30s ribosome Cryptosporidiosis treatment in AIDS patients
Niazoxanide Antiprotozoal Hydrolyzed to active metabolite. Interferes with anaerobic respiration Treats diarrhea from cryptosporidium parvum and Giardia lamblia
Chloroquine Antimalarial Interferes with feeding mechanism GI upset, retinopathy, allergic reactions. once/week dose for prophylaxis high dose, hydroxychloriquine for rheumatoid/lupus
Quinine/Quinidine Antimalarial treats chloroquine resistant. interferes with feeding, more toxic not for proph
Mefloquine Antimalarial treats resistant Psychotic/Epileptic effects
Artemisinin/Artemether Antimalarial Primary for resistan falciparum. Generates free radicals
Primaquine Antimalarial Treats tissue infections Used for follow up therapy
Pyrimethamine Antimalarial Anti folate Skin Rashes and Bone marrow suppression
Proguanil Antimalarial Antifolate treatment and prophylaxis, not in US
Pyrimethamine + Sulfadioxone Antimalarial PABA blockade and antifolate
Atovaquone + proguanil Antimalarial Antifolate + inhibition of electron transport
Doxycycline Antimalarial Phototoxicity, discoloration of teeth in children Not for children and pregnant women
Dexamethasone given during neurocysticercosis treatment
Created by: amarche1