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Pharm3test3
Question | Answer |
---|---|
Zidovudine | Nucleoside Reverse Transcriptase Can be used in pregnancy-given to mom then kid for 3 weeks Not compatible with stavudine |
Didanosine | Nucleoside Reverse Transcriptase Peripheral Neuropathy, pancreatitis |
Lamivudine | Nucleoside Reverse Transcriptase Treats Hepatitis B =Hep B flare when withdrawn |
Abacavir | Nucleoside Reverse Transcriptase Sever hypersensitivity reactions |
Emtricitabine | Nucleoside Reverse Transcriptase Lamivudine Analog Treats Hepatitis B Cause Hyperpigmentation of Palms/Soles Best tolerated |
Tenofovir | Nucleotide Reverse Transcriptase phosphorylated to nucleoside Treats Hep B No p450 action |
Nevirapine | Non-Nucleoside Reverse Transcriptase Can Cause Rash |
Evfavirenz | Non-Nucleoside Reverse Transcriptase P450 Metabolism Neural tube defects Long half life |
Ritonavir | Protease Inhibitors P450 |
Indinavir | Protease Inhibitors P450 Nephrolithiasis, skin issues |
Nelfinavir | Protease Inhibitors P450 most common used |
Atazanavir | Protease Inhibitors P450 abnormal fat distribution |
Albendazole | Antihelminthic Inhibits Microtubule Glucose Transport 1st line all the time |
Pyrantel | Antihelminthic Activates cholinergics, depolarizing neuromuscular blockade. OTC |
Praziquantel | Antihelminthic-Cestodes Causes Spastic contraction then paralysis due to calcium influx disloges jaw in cestodes. Give Mg 15-30g 2 hrs post treatment |
Metronidazole | Antiprotozoal Symptomatic, Not for use as a contact or luminal Amebicide Inhibits DNA synthesis |
Iodoquinol | Antiprotozoal Not absorbed, used for luminal Combined with metronidazole Unknown MOA |
Paromomycin | Antiprotozoal Aminoglycoside, inhibits protein synthesis binds 30s ribosome Cryptosporidiosis treatment in AIDS patients |
Niazoxanide | Antiprotozoal Hydrolyzed to active metabolite. Interferes with anaerobic respiration Treats diarrhea from cryptosporidium parvum and Giardia lamblia |
Chloroquine | Antimalarial Interferes with feeding mechanism GI upset, retinopathy, allergic reactions. once/week dose for prophylaxis high dose, hydroxychloriquine for rheumatoid/lupus |
Quinine/Quinidine | Antimalarial treats chloroquine resistant. interferes with feeding, more toxic not for proph |
Mefloquine | Antimalarial treats resistant Psychotic/Epileptic effects |
Artemisinin/Artemether | Antimalarial Primary for resistan falciparum. Generates free radicals |
Primaquine | Antimalarial Treats tissue infections Used for follow up therapy |
Pyrimethamine | Antimalarial Anti folate Skin Rashes and Bone marrow suppression |
Proguanil | Antimalarial Antifolate treatment and prophylaxis, not in US |
Pyrimethamine + Sulfadioxone | Antimalarial PABA blockade and antifolate |
Atovaquone + proguanil | Antimalarial Antifolate + inhibition of electron transport |
Doxycycline | Antimalarial Phototoxicity, discoloration of teeth in children Not for children and pregnant women |
Dexamethasone | given during neurocysticercosis treatment |