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Pharm3 test1

Penicillin G works for gram positive rods. Give with aminoglycosides for enterococcus Treat syphilis, anthrax, and actinomycetes israelii Staph is resistant
Penicillin V Better oral absorption stable in acidic conditions Less active, only used for minor infections
Penicillin procaine, benzathine suppository forms Im forms long acting procaine and benzathine are anesthetics prophylaxis for rheumatic fever during step
Methicillin Penicillinase resistant, used for staph interstitial nephritis-not used in us anymore MRSA
Nafcillin Penicillinase resistant used for staph
Oxavillin Penicillinase resistant used for staph
Ampicillin Semisythetics, more gram negative action combined with beta lactmase inhibitors (clavulanate) Expanded action for HELPSS ME effects oral contraceptives
Amoxicillin Semisythetics, more gram negative action combined with beta lactmase inhibitors (clavulanate) which expands scope Expanded action for HELPSS ME less diarrhea effects oral contraceptives Used for otitis media and sinusitis, UTIS,animal bites
Ticarcillin antipseudomonal penicillins Given with beta lactamase inhibitors treats gram negative aerobic and mixed Given with aminoglycosides sometimes Excess sodium can be bad for CHF prolongs bleeding time
Piperacillin Ureidopenicillin Broadest penicillin treats community acquired pneumonia, for non-socimial pneumonia, combine with aminoglycoside in case Ps. aeruginosa is present. Use higher doses. Used for UTIs and e coli stuff
Aztreonam "Monobactam" Highly resistant to enzymatic inactivation from gram negative only active against gram negative rods No allergies.
Imipenem Given with Cilastatin to prevent metabolism by the kidneys. Resistant to most beta lactamases, but not metallo- ones Extremely broad spectrum, powerful, used for serious hospital acquired infections use with aminoglycosides for Ps aeruginosa seizures
Meningitis the 3rd generation cephalosporins, Ceftriaxone, Ceftizoxime, and Ceftazidime, work. NOT IF LISTERIA
Cefazolin 1st generation Drug of choice for surgical prophylaxis
First generation Cephalosporins good for gram positive, modest gram negative. works for Proteus, Ecoli, Klebsiella.
Second generation Less positive, more negative Haemophilus, moraxella. Not for pseudomonas, creates mutants.
Cefuroxime Second generation, Treats strep
Third generation Much more active against gram negative, good for resistant ones. Causes enterobacter mutants.
Ceftazidime third generation, works against pseudomonas aeroginosa. meningitis.
Gonorrhea third generation, cefixime and ceftriaxone are used
Ceftriaxone Meningitis and neurological problems from lymes disease borrelia
Cefepime Fourth generation. Resistant to deactivation by chromosomal beta lactimases. used for: pseudomonas, enterobacter (UTI), and penicillin resistant Strep. And Meningitis
Ceftaroline fifth generation. Community acquired pneumonia, acute staph skin infection
Chloramphenicol Life threatening meningitis and ricketts. Used when allergies present. Possible bone marrow toxicity, aplastic anemia. Gray baby syndrome in very young babies.
Tetracyclines Cause esophagus problems and teeth problems. Take standing up with 100ml of water. BINDS CALCIUM DO NOT DO THIS OR YOUR BONES WILL DIE. TetAE pumps them out. TetM only tetracycline not for gram positive
Doxycycline Doesnt cause renal toxicity.
More Tetracyclines Gastric ulcers, chlamydia, mycoplasma pneumonia, tick diseases, periodonitis. Can cause superinfections. Demelocycycline-sun sensitivity and vasopresson inhibitions
Tigecycline IV and doesnt interfere with kidneys. Not affected by Tet resistance shit. Used for skin infections, and intra-abdominal infections
Macrolides Binds 50s. Antagonistic with chloremphanicol. Inhibit P450 enzymes except azithromycin
Erythromycin Mycoplasma pneumonia, legionella pneumophila, First line for chlamydial infections in pregnant women. Used in penicillin allergies for gram positive coccus, preventing endocarditis in dental procedures and prophylaxis for rheumatic fever. Liver toxicity.
Clarithromycin is more active against mycobacterium in AIDS and Haemophyllus
Azithromycin better po absortption, 5 days of therapy, not for sepsis, 3 day half life. One dose for chlamydia, most active against haemophylous, less against staph and strep. DOES NOT INTERFERE WITH p450
Created by: amarche1