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Hematopoietic Drugs
Drugs recognition: chap 17
Question | Answer |
---|---|
Iron (ferrous sulfate, fumarate, gluconate) | Minerals |
Iron Dextran | Minerals |
Folic Acid | Vitamins |
Vitamin B12 (cyanocobalamin, hydroxocobalamin) | Vitamins |
epoietin-alpha (Epogen) – | red blood cell stimulation |
darbopoietin-alpha (Aranasp) – | red blood cell stimulation |
filgrastim (Neupogen) – | white blood cell stimulation |
pegfilgrastim (Neulasta) – | white blood cell stimulation |
epoietin-alpha (Epogen) | Hematopoietic Growth Factors |
darbopoietin-alpha (Aranasp) | Hematopoietic Growth Factors |
filgrastim (Neupogen) | Hematopoietic Growth Factors |
pegfilgrastim (Neulasta) | Hematopoietic Growth Factors |
What is Hematopoietic Growth Factors for? | Hematopoietic deficiencies |
What are the growth factors do? | stimulate the differentiation and maturation of bone marrow cells |
what treat anemia caused by chronic renal failure, cancer chemotherapy, and zidovudin therapy, hematologic malignancies (lymphoma)) and heart failure? | epoetin and darbepoetin |
ferrous sulfate, ferrous gluconate, ferrous fumarate : indications | orally for iron deficiency anemia |
ferrous sulfate, ferrous gluconate, ferrous fumarate: adverse | GI: epigastric pain, nausea, vomiting, diarrhea, constipation, black stool, liquid will stain teeth |
what will cause lethal toxicity? | large quantity of iron |
what is iron dextran for? routes | IM and IV for iron deficiency anemia |
adverse effect of iron dextran | anaphylactin, IM: pain, sterile abscesses, brown discoloration of skin IV: flushing, hypotensive |
what are folic acid and vit B12 for? | folic acid deficiency (spina bifid), before and during pregnancy, Neural tube defects & megaloblastic anemia |
What is cyancobalamin (Vitamin B12)for? | lack of intrinsic factor, vitamin B12 deficiency, pernicious anemia, cyanide poisoning |
epoetin-α (Epogen), darbepoetin (Aranesp) indications | Chronic Renal Failure, drugs, hematologic malignancies, HF |
Hemato growth factors: epoetin, darbepoetin adverse effects | HTN, stroke, MI, HF, death |
What is Hematopoietic Growth Factors for? | Hematopoietic deficiencies |
What are the growth factors do? | stimulate the differentiation and maturation of bone marrow cells |
what treat anemia caused by chronic renal failure, cancer chemotherapy, and zidovudin therapy, hematologic malignancies (lymphoma)) and heart failure? | epoetin and darbepoetin |
ferrous sulfate, ferrous gluconate, ferrous fumarate : indications | orally for iron deficiency anemia |
ferrous sulfate, ferrous gluconate, ferrous fumarate: adverse | GI: epigastric pain, nausea, vomiting, diarrhea, constipation, black stool, liquid will stain teeth |
what will cause lethal toxicity? | large quantity of iron |
what is iron dextran for? routes | IM and IV for iron deficiency anemia |
adverse effect of iron dextran | anaphylactin, IM: pain, sterile abscesses, brown discoloration of skin IV: flushing, hypotensive |
what are folic acid and vit B12 for? | folic acid deficiency (spina bifid), before and during pregnancy, Neural tube defects & megaloblastic anemia |
What is cyancobalamin (Vitamin B12)for? | lack of intrinsic factor, vitamin B12 deficiency, pernicious anemia, cyanide poisoning |
epoetin-α (Epogen), darbepoetin (Aranesp) indications | Chronic Renal Failure, drugs, hematologic malignancies, HF |
Hemato growth factors: epoetin, darbepoetin adverse effects | HyperTension, stroke, MI, Heart Failure, death |
filgrastim (Neupogen) sargramostim (Leukine) indications | Neutropenia from chemotherapy, bone marrow transplant, leukemias |
filgrastim (Neupogen) sargramostim (Leukine) adverse effects | bone pain, spenomegaly |