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| Using which of the following techniques would enable your lab group to distinguish between a cell in G2 and a cell from the same organism in G1 | • Radioactive-labeled nucleotides
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| What is true of all cancers | • They have escaped normal cell cycle controls
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| 7. How do cancer cells differ from normal cells | • Cancer cells may be immortal
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| 8. The cell cycle control systems of cancer cells differ from those of normal cells. Select the best explanation for this fact | • Genetic changes alter the function of the cancers cell's protein products
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| 9. If a eukaryotic cell is in the G1 phase of the cell cycle, which statement about the cell's chromosomes must be correct | • Each chromosome is made of a complex of DNA and associated proteins
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| 10. Which statement provides the best description of the interphase portion of the cell cycle | • During interphase, a cell is metabolically active
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| 11. Starting with a fertilized egg (zygote), a series of five cell divisions would produce an early embryo with a how many cells | • 32
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| 12. If there are 20 chromatids in a cell, how many centromeres are there? | • 20
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| 13. At which phase are centrioles beginning to move apart in animal cells | • Prophase
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| 14. If there are 20 centromeres in a cell at anaphase, how many chromosomes are there in each daughter cell following cytokinesis | • 10
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| 15. Measurements of the amount of DNA per nucleus were taken on a large number of cells from a growing fungus. The measured DNA levels ranged from 3 to 6 picograms per nucleus. In which stage of the cell cycle did the nucleus contain 6 picograms of DNA | • G2
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| • A group of cells is assayed for DNA content immediately following mitosis and is found to have an average of 8 pictograms of DNA per nucleus. How many picograms would be found at the end of S and the end of G2 | • 16; 16
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| 17. What is a cleavage furrow | • A groove in the plasma membrane between daughter nuclei
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| 19. A plant-derived protein known as colchicine can be used by blocking the formation of the spindle. Which of the following would result in colchicine is added to a sample of cells in G2 | • The chromosomes would coil and shorten but have no spindle to which to attach
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| 26. These protists are intermediate in what sense | • They maintain a nuclear envelope during division
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| 27. What is the most probable hypothesis about these intermediate forms of cell division | • They show some but not all of the evolutionary steps toward complete mitosis
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| 28. Where do the microtubules of the spindle originate during mitosis in animal cells | • Centrosome
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| 30. Which of the following are primarily responsible for cytokinesis in plant cells but not animal cells | • Golgi-Derived Vesicles
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| 31. Movement of the chromosomes during anaphase would be most affected by a drug that prevents | • Shortening of microtubules
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| 32. During which phase of mitosis do the chromatids become chromosomes | • Anaphase
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| 33. Which of the following is release by platelets in the vicinity of an injury | • PDGF
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| 34. Which of the following is a protein synthesized at specific times during the cell cycle that associated with a kinase to form a catalytically active complex | • Cyclin
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| 35. Which of the following is a protein maintained at constant levels throughout the cell cycle that requires cyclin to become catalytically active | • Cdk
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| 36. Which of the following triggers the cell's passage past the G2 checkpoint into mitosis | • MPF
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| 37. The cyclin component of MPF is destroyed toward the end of which phase | • M
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| 38. The MPF protein complex turns itself off by | • Activating a process that destroys cyclin components
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| 39. Density-dependent inhibition is explained by which of the following | • As cells become more numerous, the cell surface proteins of one cell contact the adjoining cells and they stop dividing
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| 40. Which of the following is true concerning cancer cells | • When they stop dividing, they do so at random points in the cell cycle; they are not subject to cell cycle controls; and they do not exhibit density- dependent inhibition when growing in culture
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| 41. Which of the following describe(s) cyclin-dependent kinase (Cdk) | • Cdk is present throughout the cell cycle and is an enzyme that attaches phosphate groups to other proteins
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| 42. Why do neurons and some other specialized cells divide infrequently? | • They have been shunted into G0
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| 43. Which of the following most accurately describes a cyclin | • It activates a Cdk molecule when it is in sufficient concentration
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| 44. At the M phase checkpoint, the complex allows for what to occur | • Separase enzyme cleaves cohesions and allows chromatids to separate
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| 45. A research team began a study of a cultured cell line. Their primary observations showed them that the cell line did not exhibit either destiny-dependent inhibition or anchorage dependence. What could they conclude right away | • The cells showed characteristics of tumors
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| 46. For a chemotherapeutic drug to be useful for treating cancer cells, which of the following is most desirable | • It interferes with rapidly dividing cells
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| 47. You have a series of cells, all of which were derived from tumor, and you first need to find out which ones are malignant. What could you do | • Karyotype samples to look for unusual size and number of chromosomes
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| 49. Proteins that are involved in the regulation of the cell cycle, and that show fluctuations in concentration during the cell cycle, are called | • Cyclins
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| 50. besides the ability of some cancer cells to overproliferate, what else could logically result in a tumor | • Lack of appropriate cell death
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| 51. All cell cycle checkpoints are similar in which way | • They give the go-ahead signal to progress to the next checkpoint
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| 52. Anchorage dependence of animal cells in vitro or in vivo depends on which of the following? | • Response of the cell cycle controls to signals from the plasma membrane
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Allie58