Lecture 7 Vernino
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| Type 1 (A alpha) fibers; Morphology; Modality | show 🗑
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| show | large myelinated; vibration, pressure, stretch, touch
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| show | large myelinated; touch, temperature, and FAST pain
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| show | small, myelinated; autonomic
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| Type 4 (C) fibers; Morphology; Modality | show 🗑
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| What is an example of a large fiber disorder? | show 🗑
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| What is an example of a small fiber disorder? | show 🗑
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| show | A beta and A delta. Fast adapting receptors have a brief strong response to stimulus and then rapidly desensitizes.
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| Pascinian corpuscles; Fiber type; Structure; Function; Distribution | show 🗑
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| Meissner's corpuscles; Fiber type; Structure; Function; Distribution | show 🗑
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| Merkel cells; Fiber type; Structure; Function; Distribution | show 🗑
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| show | Excitatory
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| Are golgi tendon organ excitatory/inhibitory to agonist muscles? | show 🗑
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| Are muscle spindle proprioceptors excitatory/inhibitory to antagonist muscles? | show 🗑
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| Are golgi tendon organ excitatory/inhibitory to antagonist muscles? | show 🗑
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| show | Carried by a-delta fibers, short duration, and well localized
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| What are the characteristics of slow pain? | show 🗑
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| show | Polymodal nociceptors
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| show | The decline in the generator potential (for action potentials) given the same stimulus
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| Define nociceptive pain | show 🗑
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| Define neuropathic pain | show 🗑
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| Define allodynia | show 🗑
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| Define hyperalgesia | show 🗑
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| show | Spontaneous sensation without stimulus (pins and needles)
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| show | Painful or unpleasant paresthesia
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| show | absence of sensation
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| Define hypesthesia | show 🗑
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| Causalgia | show 🗑
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| show | A delta mechanosensitive nociceptors, A delta mechanothermal nociceptors, and C FIBERS polymodal nociceptors
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| Describe the VR-1 receptor | show 🗑
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| Describe the arousal response to pain | show 🗑
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| Describe the somatosensory response to pain (localing the pain) | show 🗑
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| show | Signals travel from EITHER the spinothalamic tract or the reticulothalamic projections to the dorsal medial nucleus of the thalamus, which the projects to the prefontal cortex, association cortex, and limbic system.
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| Describe the visceral pain pathway | show 🗑
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| show | Laminae 2 (in the substantia gelatinosa and nucleus propius)
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| Describe the structure and function of wide dynamic range neurons | show 🗑
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| What is the function of a beta fibers to WDR neurons? | show 🗑
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| How do descending inputs modulate pain? | show 🗑
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| Where do we find opioid receptors? | show 🗑
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| show | C fibers normally carry pain to the WDR neurons. In the absence of C fiber input, WDR neurons will begin to send pain signals in response to non-painful stimuli (from A fiber inputs) --> allodynia
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| show | Loss of inhibitory input to WDR neurons = enhanced WDR neuron excitation
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bloodisland