Onc Med Chem FINAL
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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| DNA Crosslinking Agents (Inhibit DNA synthesis and function) (Cell cycle phase non-specific) | Chlorambucil | Reactive species - aziridinium ion; DNA alkylation | show | PO
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| DNA Crosslinking Agents (Inhibit DNA synthesis and function) (Cell cycle phase non-specific) | Cyclophosphamide | Urotoxicity; Nephrotoxicity | show 🗑
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| DNA Crosslinking Agents (Inhibit DNA synthesis and function) (Cell cycle phase non-specific) | Ifosfamide | Urotoxicity; Nephrotoxicity to a greater extent | show 🗑
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| DNA Crosslinking Agents (Inhibit DNA synthesis and function) (Cell cycle phase non-specific) | Carmustine | DNA alkylation | Prolonged myelosuppression | show 🗑
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| DNA Crosslinking Agents (Inhibit DNA synthesis and function) (Cell cycle phase non-specific) | Lomustine | show | Prolonged myelosuppression | High lipid solubility
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| DNA Crosslinking Agents (Inhibit DNA synthesis and function) (Cell cycle phase non-specific) | Busulfan | show | Skin hyper-pigmentation (Busulfan tan); Pulmonary fibrosis; adrenal insufficiency |
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| show | Procarbazine | DNA methylation | Myelosuppression |
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| DNA Crosslinking Agents (Inhibit DNA synthesis and function) (Cell cycle phase non-specific) | Dacarbazine | DNA methylation | show |
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| DNA Crosslinking Agents (Inhibit DNA synthesis and function) (Cell cycle phase non-specific) | Cisplatin | Intra-strand DNA cross-linking (active form generated by reaction with water) | Nephrotoxicity, Ototoxicity | show 🗑
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| DNA Crosslinking Agents (Inhibit DNA synthesis and function) (Cell cycle phase non-specific) | Carboplatin | show | Myelosuppression |
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| DNA Crosslinking Agents (Inhibit DNA synthesis and function) (Cell cycle phase non-specific) | show | Intra-strand DNA cross-linking (active form generated by reaction with water) | Peripheral neuropathy |
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| Antitumor Antibiotics (Cell cycle phase non-specific) | Anthracyclines: Doxorubicin, Duanorubicin; Idarubicin; Epirubicin; Valrubicin | Inhibition of Topoisomerase IIα; Allow DNA nicking but prevent DNA religation | Cardiotoxicity (acute-ROS related; chronic-rubicinol related) | show 🗑
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| Antitumor Antibiotics (Cell cycle phase non-specific) | Bleomycin | Free radical mediated DNA strand breaks | Pulmonary fibrosis, Skin toxicity | show 🗑
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| Mitotic Inhibitors (Cell cycle M-phase specific) | show | Inhibit microtubule polymerization | Neurotoxicity |
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| Mitotic Inhibitors (Cell cycle M-phase specific) | Vinblastine | Inhibit microtubule polymerization | show |
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| Mitotic Inhibitors (Cell cycle M-phase specific) | show | Inhibit microtubule polymerization | Myelosuppression |
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| Mitotic Inhibitors (Cell cycle M-phase specific) | show | Inhibit microtubule depolymerization | Peripheral neuropathy | Hypersensitivity rxn (pre-treat patient w/ dexamethasone, H1 antagonists.
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| Mitotic Inhibitors (Cell cycle M-phase specific) | Docetaxel | Inhibit microtubule depolymerization | Fluid retention, Peripheral Neuropathy, Myelosuppression w/ neutropenia | show 🗑
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| Topoisomerase Inhibitors (Interfere with nicked DNA resealing) (Cell cycle S-phase specific) | Topotecan | Inhibit topoisomerase I | show |
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| Topoisomerase Inhibitors (Interfere with nicked DNA resealing) (Cell cycle S-phase specific) | show | Inhibit topoisomerase I | Acute and delayed diarrhea | SN-38 is the active drug; UGT1A1*28/*6 homo-or heterozygotes will have reduced irinotecan metabolism, hence increased toxicity
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| show | Etoposide | Inhibit topoisomerase II | Myelosuppression |
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| show | Teniposide | Inhibit topoisomerase II |
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| Anitmetabolites (Mimic physiologic biomolecules) (Cell cycle S-phase specific) | show | Direct Inhibition of thymidylate synthase | Myelosuppression, Hand and foot syndrome, mucositis, neurotoxicity | 5-FdUMP is the active form; Metabolic inactivation by dihydropyrimidine dehydrogenase; Leucovorin enhances drug activity
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| Anitmetabolites (Mimic physiologic biomolecules) (Cell cycle S-phase specific) | Capecitabine | show | Myelosuppression, Hand and foot syndrome, mucositis, neurotoxicity | 5-FdUMP is the active form; Metabolic inactivation by dihydropyrimidine dehydrogenase; Leucovorin enhances drug activity
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| Anitmetabolites (Mimic physiologic biomolecules) (Cell cycle S-phase specific) | Methotrexate | Inhibits DHFR Inhibits purine biosynthesis | Myelosuppression, mucositis, diarrhea | show 🗑
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| Anitmetabolites (Mimic physiologic biomolecules) (Cell cycle S-phase specific) | Pemetrexed | Inhibits DHFR Inhibits purine biosynthesis | show 🗑
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| Anitmetabolites (Mimic physiologic biomolecules) (Cell cycle S-phase specific) | 6-Mercaptopurine | show | Myelosuppression | PO available; Bioactivated by HGPRT;
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| Anitmetabolites (Mimic physiologic biomolecules) (Cell cycle S-phase specific) | show | Inhibits purine biosynthesis by inhibiting amidophosphoribosyltransferase | Myelosuppression | PO available; Bioactivated by HGPRT;
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| Anitmetabolites (Mimic physiologic biomolecules) (Cell cycle S-phase specific) | show | Inhibits DNA synthesis and repair (inhibit DNA polymerase by competing with normal nucleotides); Inhibits DNA chain elongation (by inserting at 3’ end) | Myelosuppression |
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Created by:
KaylaHaase