BIO 309 Chapter 14 -cell-cell interactions
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| show | the development and function of multicellular organisms
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| some cell-ell interactions are transient, such as the interactions between ______ and the interactions that direct ______ to _____ | show 🗑
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| stable cell-cell interactions play a role in | show 🗑
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| show | rapid communication between cells
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| cell-cell adhesion is a selective process such that | show 🗑
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| show | cell adhesion molecules
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| show | transmembrane proteins
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| show | mediate selective cell-cell adhesion
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| show | divided into 4 groups
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| show | selectins, integrins, Ig superfamily, Cadherins
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| show | selectins, integrins and most cadherins, Ca2+, Mg 2+ or Mn2+
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| show | cation
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| the selectins mediate transient interactions between | show 🗑
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| show | 3, E-selectin, P-selectin,L-selectin
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| e-selectin expressed on | show 🗑
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| p-selectin expressed on | show 🗑
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| show | leukocytes
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| selectins recognize | show 🗑
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| one of the critical roles of selectins is to initiate the interactions between __ and ___ during the migration of ____ to ____ | show 🗑
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| show | selectins, initial adhesion of leukocytes to endothelial cells
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| ICAM stands for | show 🗑
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| after initial adhesion of leukocytes to endothelial cells by selectins during inflammation, the formation of ___ occurs, in which ____ on the ____ bind to ___ | show 🗑
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| show | Ig superfamily
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| ICAMs are expressed on | show 🗑
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| After binding of ICAMs, the ____ are able to _____ and ___ | show 🗑
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| show | sites of tissue inflammation, endothelial cells, capillary walls
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| show | integrins
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| show | heterophilic interaction
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| show | an adhesion molecule on the surface of one cell recognizes a different molecule on the surface of another cell
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| homophilic interaction | show 🗑
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| show | heterophilic and homophilic
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| homophilic binding can lead to ___ between ___ | show 🗑
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| show | 100
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| show | CAMs, domains similar to immunoglobin
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| the cadherins have about ___ members | show 🗑
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| cadherins share a ____ that ____ | show 🗑
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| show | selective adhesion between embryonic cells, formation of specific synapses in the nervous system, maintenance of stable junctions between cells
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| show | cadherins
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| cell-cell interactions mediated by selectins, integrins, and Ig superfamily are generally | show 🗑
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| what are the types of cell-cell junctions | show 🗑
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| the adherens junction anchors the __ | show 🗑
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| basic components of adherens junction | show 🗑
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| show | armadillo protein
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| show | cytosolic tail of cadherins, a-catenin
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| show | b-catenin, actin
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| show | cytosolic tail of cadherins
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| show | maintain stability of junction
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| function of p120 in adherens junction | show 🗑
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| at stable cell-cell juntions, members of the protein armadillo family serve to ____ | show 🗑
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| nectin is a | show 🗑
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| nectins interact in a __ manner | show 🗑
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| nectins can also bind heterolitically to ____ in the ____ | show 🗑
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| show | nectins
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| show | recruits actin-binding proteins
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| show | assembly of the mature junction
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| show | keratin filaments, the plasma membrane
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| show | actin cytoskeleton, the plasma membrane
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| desmosomes directly link the ____ of ____ | show 🗑
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| what are the transmembrane cadherins in desmosomes | show 🗑
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| the transmembrane cadherins in desmosomes bind by ____ across the juntion | show 🗑
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| the transmembrane cadherins in desmosomes bind to the intermediate filaments via | show 🗑
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| what armadillo family proteins are present in desmosomes | show 🗑
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| what is the function of plakoglobin and plakophilin in desmosomes | show 🗑
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| show | desmoplakin
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| show | plakin family
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| show | desmoplakin
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| all components of desmosome | show 🗑
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| components of desmosome, family member, and what they bind to. | show 🗑
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| show | the intermediate filaments and the various interactions
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| ____ for the ___ and ____ allow tissue-specific variation in desmosome properties | show 🗑
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| show | epithelial cell sheets, barriers between fluid compartments
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| tight junctions play two roles in separating liquid compartments: | show 🗑
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| show | adhesive strength, junctional complex
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| show | seals of the extracellular space
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| junctional complex | show 🗑
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| tight junctions are formed by _____ that _____ | show 🗑
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| show | occludin, claudin, and junctional adhesion molecule (JAM)
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| show | similar proteins, adjacent cells
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| the cytosolic tails of the proteins in tight junctions are associated with proteins of the ___ family | show 🗑
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| show | link the junction to the actin cytoskeleton and hold it in place on the plasma membrane
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| ___ may also be present in tight junctions | show 🗑
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| show | recruiting claudins
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| show | closest known contact, adjacent cells
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| show | passage of molecules between cells
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| what links to the actin filaments in tight junctions? | show 🗑
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| JAM stands for | show 🗑
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| JAMs have ___ domains | show 🗑
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| components of tight junction | show 🗑
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| linkge to the acitn cytoskeleton in tight junctions serves to | show 🗑
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| within an individual tissue, cells are often linked by | show 🗑
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| gap junctions provide | show 🗑
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| gap junctions are ____ through the ____ that ____ | show 🗑
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| gap junctions prevent the passage of | show 🗑
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| gap junctions connect the ___ and ____ of the cells they connect | show 🗑
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| show | gap junctions
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| in electrically excitable cells, the passage of ions through gap junctions serves to _________ of ___ | show 🗑
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| show | signaling molecules, Ca2+ and CAMP, responses of cells in tissues
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| show | connexin
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| the connexins are a family of | show 🗑
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| the connexin family consists of __ human proteins | show 🗑
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| connexon | show 🗑
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| show | connexon
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| show | 6 connexins
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| how is the open channel in the gap junction formed | show 🗑
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| show | various connexons, various properties
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| an electrical synapse is made up of ___ that ____ | show 🗑
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| show | electrical synapse
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| show | depolarize, muscle cells, atria or ventricles
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| adhesion between plant cells is mediated by __, rather than by transmembrane proteins | show 🗑
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| ___ acts as a glue to hold adjacent plant cells together | show 🗑
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| show | pectin
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| show | cell wall
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| show | plasmodesmata
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| show | cytoplasmic connections through which plant cells sometimes communicate
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| plant cell walls, due to their rigiditiy, do not require the formation of ____ such as in ___ | show 🗑
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| show | gap junctions
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| integrins recognize the __ as a ligand | show 🗑
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| show | integrins, other Ig superfamily proteins
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| Cadherins recognize ___ as a ligand | show 🗑
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| show | carbohydrates
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| show | ions and small molecules
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