Antiepileptic drugs
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Drugs which lower seizure threshold? | show 🗑
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Describe Generalized seizures and describe | show 🗑
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seizure type? Sudden loss of muscle tone; may fall abruptly | show 🗑
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Seizure type? 10-30secs LOC,eye/muscle flutters; mostly CHILDHOOD; pt suddenly stops what they're doing and resumes postictus | show 🗑
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Drugs used for Absence Seizures? ***** | show 🗑
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Seizure type? Max neurons of both hemis; begin w/ tonic(rigid) flexion of extremities 15-20 sec.s followed by extension; audible cry; Then clonic jerking phase;LOC | show 🗑
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show | Myoclonic Seizures
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show | Tonic Seizures
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Seizure type? One hemisphere | show 🗑
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Name the 2 types of partial seizures, and describe them | show 🗑
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This seizure type starts with specific motor sensory or psychomotor phenomenon w/o LOC; ofter preceded by aura/specific smell | show 🗑
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show | Lennox-Gestaut Syndrome--mostly tonic and myoclonic
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show | Complex Partial Seizures *** Caution must be used cuz Neuroleptic used may decrease threshold for epilepsy
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show | Status epilepticus
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show | Benzodiazepam/Clonazepam
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Seizures that is triggered by hyperthermia; mostly young kids (3mo-5yrs)---poss. causes--meningitis | show 🗑
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highly lipophilic, structure related to IMIPRAMINE (TRICYCLIC),effective for Tonic-Clonic &Partial Seizures | show 🗑
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DOC for partial seizures | show 🗑
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show | Autoinduction;**** P-450 inducer(reduces other meds); CARDIAC CONDUCTION DISTURBANCES***
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show | heart conduction disturbances; dizzy/drowsy/anorexia/nausea/ataxia/diplopia/depression/mental sluggish/rash/short term mem decreases; hyponatremia & H2O retention
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show | Increases:Theophylline,OC's,Doxycycline, Warfarin Decreases: Verapamil, Fluoxetine, Diltiazem, Isoniazid, Erythromycin
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show | Valproate
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show | Valproate
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Valproate MOA? | show 🗑
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Valproate--protein or lipo bound? | show 🗑
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Adverse effects of Valproate? | show 🗑
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Avoid Valproate in what type of patients? name 3 | show 🗑
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show | Ethosuxomide
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show | inhibitor!! will increase levels of co-administered AED
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This AED is contraindicted in pregnancy | show 🗑
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show | Valproate
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Phenytoin can be used as anti-epileptic and as what? | show 🗑
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show | Blocks Na&Ca channels and Ca+mediated neurotransmission/electrical activity
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show | Generalized and Partial epilepsy---NOT effective against absence seizure
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Adverse effects of Phenytoin? | show 🗑
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Deficiency of what? is ass'd with Phenytoin use? | show 🗑
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Phenytoin= P450....? | show 🗑
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Phenytoin can be displaced by what other AED? | show 🗑
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Phenytoin + Valproate=?? | show 🗑
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show | Blocks Ca channels in Thalamus
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show | Blood dyscrasias, sedation, nausea, anorexia, headache
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show | prolongs Cl-channel opening @GABA receptor
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show | Phenobarbital<Primidone
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Adverse effects of Phenobarbital and Primidone? | show 🗑
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Adverse effect Primidone? | show 🗑
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show | Phenobarbital&Phenylethylmalonamide
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Diazepam and Clonazepam-classification? | show 🗑
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Tx of termination of status epilepticus**** and febrile seizures; adverse effects? | show 🗑
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strucural analog of GABA that enhances its release; used for partial seizrures, tonic clonic, neuropathic pain, mood stabilizers | show 🗑
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Blocks release of excitatory Amino acids(glutamate); increases GABA levels; used for partial seizures | show 🗑
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show | Lamotrigine
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This med inhibits metabolism of Latorigine | show 🗑
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Analog of GABA; increases levels; uses:partial and focal seizures | show 🗑
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Side effect of Vigabatrin | show 🗑
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show | Levitriacetam
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show | binds synaptic vesicle protein SV2A to impede nerve conduction across synapses
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show | k;
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show | Valproate
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show | Phenytoin, Carbamazepine, Phenobarbital
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show | Valproate, Gabapentin, Carbamazepine
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To assess tx failures, non-compliance/malabsorption, guide dose adjustments, evaluate drug related adverse effects...do what? | show 🗑
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This AED causes neural tube defects in fetus | show 🗑
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show | Phenytoin
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Safest AED in Pregnancy for Grand Mal and Partial epilepsy? | show 🗑
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Clotting should be monitored and Vit K is given (deficient) by IM to baby immediately after birth (1mg) if what meds were taken by mom? | show 🗑
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show | AED's are lipophilic (go to brain) therefore get passed through milk
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show | Grand mal
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show | Primidone
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alcohol is P450 inducer therefore it ___'s phentoin | show 🗑
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Phenytoin can ____OC efficacy | show 🗑
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show | increase
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Gabapentin and Lamotrigine effective in ___ seizures | show 🗑
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show | simple partial
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hirsuitism...ass'd w/ chronic administration of what drug? | show 🗑
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show | GABAPENTIN, caramazepine, phenytoin
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show | Valproate
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show | Stop phenytoin and change to Carbamazepine
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Created by:
alexinagonzalez