Antiepileptic drugs
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| Drugs which lower seizure threshold? | show 🗑
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| Describe Generalized seizures and describe | show 🗑
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| show | atonic seizure (generalized)
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| Seizure type? 10-30secs LOC,eye/muscle flutters; mostly CHILDHOOD; pt suddenly stops what they're doing and resumes postictus | show 🗑
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| Drugs used for Absence Seizures? ***** | show 🗑
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| show | Tonic-Clonic Seizures (grand mal)
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| Seizure type? jerking movements of single/multiple muscle group; no LOC | show 🗑
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| show | Tonic Seizures
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| show | partial seizure due to injury, trauma, stroke, tumor
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| show | Complex partial-LOCSimple partial-NO LOC
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| This seizure type starts with specific motor sensory or psychomotor phenomenon w/o LOC; ofter preceded by aura/specific smell | show 🗑
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| Difficult form of childhood epilepsy (mostly nocturnal)2-6yrs old; Characterized by frequent and different seizure types, M.R., & behavioral problems; | show 🗑
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| 1-2 min. dissociation w/ surroundings; stagger, mental confusion 1-2 minutes;over originates in temporal lobe-Schizo,depression | show 🗑
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| show | Status epilepticus
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| Status epilepticus...DOC? | show 🗑
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| show | 1.)FEBRILE seizures(fever fit); Simple febrile seizure= ~15min& 1episode/24hrs 2.)Complex febrile seizure= LONGER&RECURS; 3.)tonic-clonic
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| highly lipophilic, structure related to IMIPRAMINE (TRICYCLIC),effective for Tonic-Clonic &Partial Seizures | show 🗑
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| show | Carbamazepine
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| Caution with Carbamazepine...name 2 reasons why: | show 🗑
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| Carbamazepine:adverse effects | show 🗑
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| show | Increases:Theophylline,OC's,Doxycycline, Warfarin Decreases: Verapamil, Fluoxetine, Diltiazem, Isoniazid, Erythromycin
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| show | Valproate
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| show | Valproate
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| show | potentiates GABA, Na&Ca blockade (decreases neurotransmission)
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| show | protein bound---therefore can be easily displaced by others etc.
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| Adverse effects of Valproate? | show 🗑
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| Avoid Valproate in what type of patients? name 3 | show 🗑
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| show | Ethosuxomide
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| Valproate...P450------? | show 🗑
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| This AED is contraindicted in pregnancy | show 🗑
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| This AED doesn't reduce efficacy of OC | show 🗑
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| show | ANTI-ARRHYTHMIC!!!!
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| MOA of Phenytoin? | show 🗑
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| Phenytoin effective for what types of seizures? | show 🗑
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| Adverse effects of Phenytoin? | show 🗑
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| Deficiency of what? is ass'd with Phenytoin use? | show 🗑
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| show | inducer, therefoere increases metabolism of theophylline, OC's, carbamazepine, and valproate
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| show | Valproate
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| show | Valproate displaces Phenytoin--> increased free fraction of Phenytoin-->higher adverse effects of Phenytoin
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| MOA Ethosuximide? | show 🗑
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| Adverse effects Ethosuximide? | show 🗑
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| MOA Phenobarbital & Primidone? | show 🗑
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| Drugs for CHRONIC tx of epilepsy? partial and generalized seizures | show 🗑
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| show | Osteomalacia; Paradoxical effects (hyperactivity&insomnia); P450 inducers
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| show | impotence
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| Primidone is a prodrug converted to | show 🗑
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| show | Benzodiazepines for tx. of epilepsy
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| show | Benzodiazepines; Excess salivation, wt. gain, anterograde amnesia
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| strucural analog of GABA that enhances its release; used for partial seizrures, tonic clonic, neuropathic pain, mood stabilizers | show 🗑
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| Blocks release of excitatory Amino acids(glutamate); increases GABA levels; used for partial seizures | show 🗑
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| Blocks Na channels and inhibits excitatory AA's; uses-partial&generalized szrs; short 1/2 life | show 🗑
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| This med inhibits metabolism of Latorigine | show 🗑
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| Analog of GABA; increases levels; uses:partial and focal seizures | show 🗑
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| show | can exacerbate absence/myoclonic seizures
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| show | Levitriacetam
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| MOA of Levitiracetam | show 🗑
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| Slide 32?? | show 🗑
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| P450 AED inhibitors? | show 🗑
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| show | Phenytoin, Carbamazepine, Phenobarbital
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| Antiepilectic drugs that are mood stabilizers?**** | show 🗑
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| show | check blood levels
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| This AED causes neural tube defects in fetus | show 🗑
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| show | Phenytoin
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| Safest AED in Pregnancy for Grand Mal and Partial epilepsy? | show 🗑
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| show | Phenobarb, Phenytoin, Primidone
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| Baby of mom taking AED is lethargic...why? | show 🗑
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| show | Grand mal
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| it's antiseizure activity is due to its metabolism to Phenobarbital and Phenylethylmalonide | show 🗑
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| alcohol is P450 inducer therefore it ___'s phentoin | show 🗑
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| Phenytoin can ____OC efficacy | show 🗑
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| Valproate can cause Phenobarbital to ___ | show 🗑
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| show | complex partial
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| show | simple partial
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| show | Phenytoin
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| show | GABAPENTIN, caramazepine, phenytoin
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| show | Valproate
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| 6wk preggers lady with seizure disorders...she takes phenytoin? please advise... | show 🗑
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