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Med Chem Test #3

Quiz yourself by thinking what should be in each of the black spaces below before clicking on it to display the answer.
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Drug Name
Chem Class
Pharm Class
MOA
Sumatriptan   Beta-Indole ethylmine   5-HT1 Serotonin agonist   Selective 5-HT1d receptor agonism  
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Naratriptan   Beta-Indole ethylmine   5-HT1 Serotonin agonist   Selective 5-HTb & 1d receptor agonism  
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Zolmitriptan   Beta-Indole ethylmine   5-HT1 Serotonin agonist   Selective 5-HT1b & 1d receptor agonism  
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Rizatriptan   Beta-Indole ethylmine   5-HT1 Serotonin agonist   Selective 5-HT1b & 1d receptor agonism  
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Almotriptan   Beta-Indole ethylmine   5-HT1 Serotonin agonist   Selective 5-HT1b & 1d receptor agonism  
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Frovatriptan   Beta-Indole ethylmine   5-HT1 Serotonin agonist   Selective 5-HT1b & 1d receptor agonism  
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Eletriptan   Beta-Indole ethylmine   5-HT1 Serotonin agonist   Selective 5-HT1b & 1d receptor agonism  
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Ondansetron   Indole   5-HT3 Antagonist   5-HT3 receptor antagonism  
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Granisetron   Indole   5-HT3 Antagonist   5-HT3 receptor antagonism  
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Dolasetron   Indole   5-HT3 Antagonist   5-HT3 receptor antagonism  
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Palonosetron   Indole   5-HT3 antagonist   5-HT3 receptor antagonism  
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Aprepitant   (blank)   Substance P/Neurokinin 1 antagonist   (blank)  
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Alosetron   Pyridoindolone   Neuroenteric modulator   5-HT3 antagonism  
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Tegaserod   Indole   (blank)   5-HT4 partial agonist  
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Phenelzine   Hydrazine   Antidepressant   Irreversibly inhibits MAO  
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Isocarboxazid   Hydrazide   Antidepressant   Irreversibly inhibits MAO  
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Tranylcypromine   Cyclopropylamine   Antidepressant   Reversibly inhibits MAO  
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Imipramine   Dibenzazepine   Antidepressant   Inhibits uptake of 5-HT, NE  
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Desipramine   Dibenzazepine   Antidepressant   Inhibits uptake of 5-HT, NE  
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Amitryptyline   Dibenzazepine   Antidepressant   Inhibits uptake of 5-HT, NE  
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Nortryptyline   Dibenzazepine   Antidepressant   Inhibits uptake of 5-HT, NE  
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Trimipramine   Dibenzazepine   Antidepressant   Inhibits uptake of 5-HT, NE  
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Protryptyline   Dibenzazepine   Antidepressant   Inhibits uptake of 5-HT, NE  
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Doxepin   Dibenzoxapine   Anxiolytic/Antidepressant   Inhibits uptake of 5-HT, NE  
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Amoxapine   Dibenzoxazepine   Anxiolytic/Antidepressant   Inhibits uptake of 5-HT, NE, blocks DA  
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Clomipramine   Dibenzazepine   Antidepressant   Inhibits uptake of 5-HT, NE  
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Bupropion   Beta-phenethylamine   2nd Gen. Antidepressant   Weak inhibitor of uptake of NE, 5-HT, DA  
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Maprotilline   Tetracyclic   2nd Gen. Antidepressant   Inhibits NE uptake  
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Mirtazapine   Tetracyclic   2nd Gen. Antidepressant   5-HT2, 5-HT3 antag. and alpha2-antag.  
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Venlafaxine   Beta-phenethylamine   2nd Gen. Antidepressant   Inhibits NE/5-HTuptake (NSRI)  
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Trazodone   Phenylpiperazine   2nd Gen. Antidepressant   Inhibits 5-HT uptake/5-HT2 receptor antag.  
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Nefazodone   Phenylpiperazine   2nd Gen. Antidepressant   Inhibits 5-HT uptake/ 5-HT2 receptor antag.  
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Fluoxetine   Arylbutylamine   SSRI   Sel. inhibits 5-HT uptake (SSRI)  
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Sertraline   Arylbutylamine   SSRI   Sel. inhibits 5-HT uptake (SSRI)  
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Paroxetine   Arylbutylamine   SSRI   Sel. inhibits 5-HT uptake (SSRI)  
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Citalopram   Arylbutylamine   SSRI   Sel. inhibits 5-HT uptake (SSRI)  
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Fluvoxamine   Oxime   SSRI   Sel. inhibits 5-HT uptake (SSRI)  
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Reboxetine   Arylbutylamine   SNRI   Sel. NE reuptake inh.  
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Duloxetine   Arylbutylamine   NSRI   Inhibits reuptake of NE and 5-HT  
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Doxapram   Amide   Analeptic   Medullary stimulant  
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Lobeline   Alkaloid   Analeptic   Reflex stimulant  
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Strychnine   Alkaloid   Analeptic   Glycine antagonist  
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Pentylenetetrazole   Tetrazole   Analeptic   Medullary stimulant  
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Caffeine   Xanthine   CNS stimulant   Phosphodiesterase inhib. and P1-(A1) adenosine antag.  
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Theophylline   Xanthine   CNS stimulant   Phosphodiesterase inhib. and P1-(A1) adenosine antag.  
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Theobromine   Xanthine   CNS stimulant   Phosphodiesterase inhib. and P1-(A1) adenosine antag.  
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Amphetamine   Beta-phenethylamine   CNS stimulant   Inc. DA release from central neurons  
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Methamphetamine   Beta-phenethylamine   CNS stimulant   Inc. DA release from central neurons  
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Methylphenidate   Beta-phenethylamine   CNS stimulant   Blocks DA uptake  
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Pemoline   Beta-phenethylamine   CNS stimulant   Inc. DA release from central neurons  
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Modafanil   Misc.   CNS stimulant   Activates orexin neurons  
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Phentermine   Beta-phenethylamine   Anorexic agent   Inc. NE release from central neurons  
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Benzphetamine   Beta-phenethylamine   Anorexic agent   Inc. NE release from central neurons  
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Phenmetrazine   Beta-phenethylamine   Anorexic agent   Inc. NE release from central neurons  
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Phendimetrazine   Beta-phenethylamine   Anorexic agent   Inc. NE release from central neurons  
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Diethylpropion   Beta-phenethylamine   Anorexic agent   Inc. NE release from central neurons  
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Fenfluramine   Beta-phenethylamine   Anorexic agent   Inc. NE release from central neurons  
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Sibutramine   Beta-phenethylamine   Anorexic agent   Inhibits NE/5-HT uptake  
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Mazindol   Imidazoline   Anorexic agent   Inhibits uptake of NE  
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Orlistat   Misc.   Anorexic agent   Irreversibly inhibits lipase  
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Morphine   Morphine der.   Central analgetic agonist   Opioid receptor agonism  
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Hydromorphone   Morphine der.   Central analgetic agonist   Opioid receptor agonism  
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Hydrocodone   Morphine der.   Central analgetic agonist   Opioid receptor agonism  
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Codeine   Morphine der.   Central analgetic agonist   Opioid receptor agonism  
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Nalbuphine   Morphine der.   Mixed agon-antag analgetic   Opioid receptor agonism  
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Buprenorphine   Oripavine   Mixed agon-antag analgetic   Opioid receptor agonism  
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Levorphanol   Morphinan   Central analgetic agonist   Opioid receptor agonism  
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Butorphanol   Morphinan   Mixed agon-antag analgetic   Opioid receptor agonism  
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Pentazocine   Benzomorphan   Mixed agon-antag analgetic   Opioid receptor agonism  
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Meperidine   Piperidine   Central analgetic agonist   Opioid receptor agonism  
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Diphenoxylate   Piperidine   Antidiarrheal   Intestinal opioid agonist  
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Loperamide   Piperidine   Antidiarrheal   Intestinal opioid agonist  
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Methadone   Diphenylpropylamine   Central analgetic agonist   Opioid receptor agonism  
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Levomethadyl acetate   Diphenylpropylamine   Central analgetic agonist   Opioid receptor agonism  
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Propoxyphene   Diphenylpropylamine   Central analgetic agonist   Opioid receptor agonism  
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Fentanyl   4-anilidopeperidine   Central analgetic agonist   Opioid receptor agonism  
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Sufentanil   4-anilidopeperidine   Central analgetic agonist   Opioid receptor agonism  
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Alfentanil   4-anilidopiperdine   Central analgetic agonist   Opioid receptor agonism  
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Remifentanil   4-anilidopiperdine   Central analgetic agonist   Opioid receptor agonism  
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Methotrimeprazine   Phenothiazine   Central analgetic   Raise pain threshold  
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Dezocine   Aminotetralin   Mixed agon-antag analgetic   Mixed opioid agonist-antagonist  
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Tramadol   Misc.   Central/peripheral analgetic   Opioid receptor agonist/peripheral 5-HT/NE uptake inhib.  
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Nalorphine, Naloxone, Naltrexone, Nalmefene   Morphine Der.   (blank)   Narcotic Antagonism  
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