MicroPharm
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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| Block cell wall synthesis by inhibition of peptidoglycan crosslinking | show 🗑
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| block peptidoglycan synthesis | show 🗑
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| block nucleotide synth by inhib folic acid synthesis - involved in methylation | show 🗑
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| show | fluroquinolones (-floxacin)
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| block mRNA synthesis | show 🗑
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| Damage DNA | show 🗑
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| show | CCELS at 50
Choramphenicol,
Clindamycin
Erythromycin (macrolides)
Streptogramins - quinupristin, dalfopristin, linozolid
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| Block protein syneth at 30S ribosomal subunit | show 🗑
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| show | Clavulanic Acid
Sulbactam
Tazobactam
(CAST)
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| show | Extended spectrum penicillin - HELPSS kill Enterococci
- H. flu
- E. coli
- Listeria monocytogenes
- Proteus mirablilis
- Salmonella
- Shigella
ENTEROCOCCI
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| show | L Listeria
A Atypicals (Chlamydia, Mycoplamsa)
M MRSA - except ceftaroline
E Enterococci
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| show | cefAZOLin, cephALEXin
PEcK - Proteus, Ecoli, Kelbs
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| show | cefazolin
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| 2nd Gen Cephs | show 🗑
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| show | aztreonam - gram negative rods ONLY
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| cilatatin | show 🗑
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| show | Vancomycin
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| Red man syndrome - cause and prevention | show 🗑
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| show | NOT + Red man syndrome
Nephrotox
Ototox
Thrombophebitis
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| show | aminoglycoside
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| show | macrolides - macroSLIDES binds to the 23S rRNA
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| show | clindamycin
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| prevent attachment to amino acyl tRNA | show 🗑
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| prevents attachment of 50S to other parts of the ribosomal unit | show 🗑
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| show | Aminoglycosides: GNATS
Gentamicin, Neomycin, Amikacin, Tobramycin, Streptomycin
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| show | Neomycin
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| resistance by transferase enzymes: acetylation, phosphorylation or adenylation | show 🗑
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| show | Demeclocycline - a tetracycline
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| show | Tetracyclines
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| methylation at 23S rRNA | show 🗑
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| Macrolide toxicity | show 🗑
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| lack of UDP glucuronyl transferase | show 🗑
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| pseudomembranous colitis | show 🗑
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| PABA antimetabolites inhibit dihydropteroate syntase | show 🗑
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| hemolysis if G6PD def + kernicterus in infants | show 🗑
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| show | Fluroquinolones
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| show | Metronidazole
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| show | Metronidazole
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| show | P: Isoniazide
Tx: RIPE - Rifampin, Isoniazid, Pyrazinamide, Ethambutol
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| M. avium-intracellulare - proph | show 🗑
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| show | P: n/a
Tx: Tuberculoid: Dapsone + Rifampin
Lepromatous: Dapsone+Rifampin + Clofazimine
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| show | Isoniazid
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| dec synth of mycolic acid | show 🗑
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| prevents neurotoxicity of isoniazid | show 🗑
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| inhibits DNA-dependent RNA polymerase | show 🗑
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| show | rifampin
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| acidify intracellular environment | show 🗑
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| decrease carbohydrate polymerization of mycovaterium cell wall by blocking arabinosyltranserase | show 🗑
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| show | ethambutol
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| meningococcal infection | show 🗑
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| show | ceftriaxone
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| syphilis | show 🗑
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| show | TMP SMX
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| show | TMP SMX; dapsone
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| show | penicillins
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| show | ampicillin
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| show | oral penicillin
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| prevention of post surgical infection due to S. aureus | show 🗑
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| show | rifampin
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| show | erythromycin ointment
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| show | vancomycin, linezolid
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| show | linezolid, streptogramin
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| show | Amphotericin B
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| Clinical Use for Amphotericin B | show 🗑
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| show | Nystatin; swish and swallow; thrush, diaper rash; vaginal
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| show | -azoles
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| show | fluconazole
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| show | fluconazole
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| blastomyces | show 🗑
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| coccidiodes | show 🗑
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| show | itraconazole
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| gynecomastia | show 🗑
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| show | Flucytosine --> 5-FU
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| show | flucytosine --> 5-FU
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| bone marrow suppression | show 🗑
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| Inhibits cell wall synthesis by inhibiting synthesis of B-glucan | show 🗑
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| Invasive aspergillosis Candida | show 🗑
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| inhibits the fungal enzyme squalene epoxidase | show 🗑
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| tx for dermatophytoeses | show 🗑
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| show | griseofulivin
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| show | griseofulvin
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| show | griseofulvin
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| show | pyrimethamine
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| show | suramin
melarsoprol
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| show | nifurtimox
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| show | sodium stibogluconate
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| show | Chloroquine: Heme accumulates and is toxic to plasmoida
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| show | pumpt that dec intracellular concentration of drug.
Use: artemether/lumifantrine or atovaquone/proguanil
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| show | quinidine
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| chloroquine toxicity | show 🗑
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| show | Bendazole or pyrantal
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| Strongylodies | show 🗑
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| Onchocerca | show 🗑
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| show | Diethylcarbamazine
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| show | Albendazole or mebendazole
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| Tapeworms: Taneia solium; Diphyllobotrium latum | show 🗑
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| show | Bendazoles
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| show | bendazoles
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| show | Praziquantel
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| show | zanamivir, oseltamivir
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| show | Ribavirin
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| Guanosine analog. Inhibits viral DNA polymerase by chain termination | show 🗑
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| show | HSV-1; HSV-2; VZV; weakly EBV
NO CMV!!!!!
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| show | Gancyclovir
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| show | Gancyclovir
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| show | Foscarnet
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| CMV retinitis in immunocompromised patients | show 🗑
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| preferentially inhibits viral DNA polymerase NO phosphorylation by viral kinase | show 🗑
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| show | coadmin w/ probenecid and IV saline --> dec nephrotoxicity
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| show | - 2 NRTIs - nucleoside reverse transcriptase inhibitors +
(1 NNRTI - nonnucleoside rev transcriptase inhib OR
1 protease inhib OR
1 integrase inhib)
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| prevents maturation of new viruses | show 🗑
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| nucleoTide analog that does not have to be activated | show 🗑
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| show | G-CSF and erythropoietin
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| show | -vudine/-nosine
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| Bind to reverse transcriptase does not require phosphorylation | show 🗑
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| Bind to reverse transcriptase requires phosphorylation | show 🗑
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| show | Nevirapine
Dlavirenze
Delavirdine
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| show | Raltegravir - integrase inhibitor
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| Glycoprotiens synthesized by virus infected cells Block replication of both RNA and DNA viruses | show 🗑
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| IFNa | show 🗑
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| IFNb | show 🗑
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| show | NADPH oxidase deficiency
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| pt has HIV, hepatitis, neutropenia and myopathy. whats he taking? | show 🗑
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| show | FAACE
Fluroquinolones
Aztreonam
Aminoglycosides
Cefepine
Extended Spectrum Penicillins
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| show | ACE
Amoxicillin
Clindamycin
Erythromycin
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| NEVER USE IN PREGNANCY (1) | show 🗑
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| NEVER USE IN PREGNANCY (2) | show 🗑
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Created by:
Suny510