2/20 quiz LEC Word Scramble
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Question | Answer |
Muscle Tissue Functions (3) | Movement, Posture, Heat Production |
Skeletal Muscle Tissue type is | Connective Tissue (Fibrous) |
CT types found in skeletal tissue (3) | Epimysium, Perimysium, Endomysium |
Epimysium, Perimysium, Endomysium combine to form | tendon that combines with periosteum of bone |
Epimysium | surrounds entire muscle |
Perimysium | surrounds muscle fiber bundles |
Endomysium | surrounds each muscle fiber |
the merging of the tendon and periosteum of bone is | strong bond, slow to heal |
muscle cells are called | muscle fibers (myofibers) |
within each muscle cell we have (5) | sarcolemma, sarcoplasm, sarcoplasmic reticulum, transverse tubules (T tubules), myofibrils |
sarcolemma | cell membrane |
sarcoplasm | cytoplasm |
sarcoplasmic reticulum | smooth ER with dilaetd sacs called terminal cristernae which contain calcium ions |
transverse tubules (T tubules) | extensions of the sarcolemma that run perpendicular to the sarcolemma |
myofibrils | small fibers within the myofiber |
each myofibril consists of | a series of repeating sarcomeres, the basic unit of contraction |
sarcomeres | the basic unit of contraction |
sarcomeres run from | Z line to Z line |
Sarcomeres consist of | alternating A (dark) and I (light) bands |
In the center of the A band | is a slightly lighter H zone |
when the muscle (sarcomere) contracts (4) | 1. the Z lines come closer 2. the I band gets smaller 3. the H zone disappears 4. the A band remains the same |
the I band components must slide over the A band components | Sliding Filament Theory |
thin filaments | extend from the Z lines. Make up the I band and A band, which is exclusive of the H zone |
Thin filaments are made up of | Proteins: Actin, Tropomyosin, Troponin |
Actin | globular proteins that possess a myosin binding site |
Tropomyosin | strands that cover the myosin binding site on the actin |
Troponin | located at regular intervals on the tropomyosin |
Thick Filaments | make up the A band |
Thick filaments are made up of | myosin: club-shaped protein |
Thick filaments possess a | cross-bridge (head) |
cross-bridge (head) consist of | an actin-binding site and an ATP binding site |
During contraction, a nerve impulse causes | synaptic vesicles in the motor axon end bulbs to release acetylcholine by exocytosis |
During contraction, the impulse does not simply "jump" from neuron to muscle. What happens? | ACh diffuses across the synaptic cleft within the NMJ and initiates an impulse that spreads over the surface of the sarcolemma. |
the impulse enters the T tubule and | stimulates the sarcoplasmic reticulum to open channels to release calcium ions from storage into the sarcoplasm |
calcium ions combine with | the tropinin which changes shape. This causes the troponin-tropomysoin complex to move, thus exposing the myosin binding sites on the actin |
the cross bridge is energized with | energy from an ATP |
the actin binding site combines with | the myosin binding site |
the cross bridge then uses its energy to | Powerstroke: bend the bridge which pulls the actin along (sliding filament) |
the sliding draws the z lines | closer together thus shortening the sarcomere and the muscle |
ATP binds with the | ATP binding site thus breaking the bridge and energizing the bridge for another power stroke |
once the impulses stop, | calcium ions are actively transported back to the sarcoplasmic reticulum. |
To relax the muscle | It takes ATP |
The (high or low?) calcium ion concentration in the sarcoplasm allows | low. the tropomyosin/troponin complex to cover the myosin binding sites. Myosin cross bridges seperate from the actin. |
sarcomeres return to their resting lengths | and the muscle relaxes |
Neuromuscular Junction (NMJ) | the joining of a nerve cell (neuron) and a muscle cell. No physical contact. Only one per muscle. |
Motor end plate | region of the sarcolemma adjacent to the neuron terminal |
the neuron terminal contains | vesicles filled with neurotransmitter |
the motor end plate contains | many neurotransmitter receptors |
the space between the neuron and the muscle fiber | cleft |
a nerve impulse causes | calcium ions channels to open allowing calcium to enter the axon. This somehow causes the vesicles to fuse with the neuronal membrane releasing the neurotransmitter, ACh, into the cleft |
ACh combines with | the receptor sites and alters the membrane's permeability to Na and K ions (ie generates an impulse on the muscle membrane) |
ACh in inactivated by the | sarcolemma protein, no acetylcholinesterase (AChE). As a result, ACh no longer affects the NMJ |
curare | drug that acts as competitive inhibitor with acetylcholine |
botulinum toxin | a toxin from a bacterium that prevents the release of ACh |
Myasthenia gravis | an autoimmune disease that destroys the muscle Ach receptors. Causes muscle weakness, not life threatening |
autoimmune disease | diseases whereby we produce antibodies that attack our own tissues |
idiopathic | unknown cause |
motor unit | the motor neuron and all the muscle fibers it stimulates |
motor unit range | 10 (precision) to 2000 (gross) fibers per unit |
ALL-OR-Nothing Principle | When a muscle fiber* contracts, it contracts all-the-way given the same starting point. (gun trigger) |
all muscle fibers of a given unit will | contract all the way |
recruitment | increasing the number of active motor units. Brain does this. Thus, more muscle strength of contraction |
muscle tone | minimum number of motor units that are always active. Enough to make the muscle tense, but not enough to produce movement. more active=more active units |
100 motor units and 50 fibers/unit = | 5000 fibers/muscle |
flacid | cut the *NMJ |
twitch | single muscle response to a single stimulus |
twitch consists of (3) | latent period, period of contraction, period of relaxation |
tetanus | a sustained contraction in response to frequent stimuli |
refractory period | a period of time following a stimulus whereby the muscle fiber loses its excitability and connot respond to another stimulus. refuses to respond |
wave summation | occurs when a stimulus is applies AFTER the refractory period but the muscle has not completely relaxed. The second wave adds on to the first. different starting points. |
incomplete tetanus | a sustained contraction in response to high frequency stimuli but with attempts at relaxation. These are out everyday activities |
complete tetanus | a sustained contraction (with no relaxation) in response to a very high frequency of stimulation. Perhaps seen when lifting an elephant. |
isotonic contraction | Movement: muscle shortening with little increase in tension. Increases strength |
isometric contraction | No Movement: minimal shortening with great increase in tension. 2 sets muscle contractions. increases size |
how does length influence strength of a contraction | muscle fibers contract minimally when at optimal length, attained when muscle is slightly stretched. stregth of contraction reflects degree of overlap of the thick and thin filaments. over-stratching produces a decrease in the strength of a contraction |
muscle fibers do NOT | undergo mitosis. Only size of the CELL gets larger or smaller |
Atrophy | decrease in individual muscle cell size |
Hypertrophy | increase in individual muscle cell size |
immediate energy source for a contraction | ATP |
ATP energy time for exercise | 5-6 seconds |
after 15 seconds | glycolysis kicks in |
5-15 seconds | Phosphocreatine (PC): high energy molecule that replenishes ATP stores |
ADP + PC ---> | ATP + C |
Oxygen debt | build up of lactic acid - need O2 to get rid of pyruvic acid |
Glycolysy (anaerobic provides | 2 ATP molecules/glucose.. |
The Krebs Cycle (aerobic) provides | 36 ATPs/glucose. But it is limited by the availability of oxygen and NAD+ |
during intense exercise,Krebs cycle | cant keep up |
krebs cycle limitation is overcome by | catabolizing many molecules of glucose by glycolysis (anaerobic) |
pyruvic acid begins to build up and is converted to | lactic acid (pain, fatigue) |
lactic acid is disposed of by | the taking in of additional oxygen after exercise (heavy breathing). This build up of acid creates oxygen debt. Heavy breathing after exercuse pays back the debt. |
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la66
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