Pharm 44 Immunosupr Word Scramble
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Question | Answer |
Azathioprine AZA Class? | Cytotoxic- Antimetabolite |
Methotrexate MTX Class? | Cytotoxic- Antimetabolite Mycophenolic Acid Class ? |
Mycophenolate Mofetil Class ? | Cytotoxic- Antimetabolite |
Leflunomide Class? | Cytotoxic – Antimetabolite |
Use in Renal transplant, IBS, and RA. Causes pancreatitis and hepatotoxicity | Azathiprene |
Use in tumors, autoimmune. Folate analogue inhibits DHFR | methotrexate |
Cyclophosphamide Class? | Alkylating agent |
Used almost exclusively with SLE or xenotransplants. Causes bladder cancer | cyclophosphamide |
Used to prevents cyclophosphamide bladder cancer | mesna |
Don’t give oral iron with this drug | Mycophenolate mofetil |
(2) Can cause GI bleed, lymphoma. Tx: solid organ, lupus nephritis, RA, Pemphigus | Mycophen-olic acid /-olate mefetil |
Tx: RA Hepatotoxic (long action). Causes lung disease CI:Pregnancy | leflunomide |
Adverse Effects: interstitial fibrosis, nephrotoxic, HTN, HCh, hepatotoxic | cyclosporine |
Tx: chronic dry eyes, organ transplant, RA, psoriasis. MOA: inhibits IL-2 release | cyclosporine |
Tx: organ transplant, atopic dermatitis SE: nephron, htn, prolong QT | Tacrolimus |
This is incorporated into coronary stents to prevent coronary artery smooth muscle proliferation | Sirolimus |
Tx: Organ transplant No nephrotoxicity SE: HTN, HLip, thrombocytopenia | Sirolimus |
Can cause demyelinating disease of CNS Tx: Psoriatic arthritis Blocks TNF- a & b | Etanercept |
Can cause demyelinating disease of CNS Tx: Psoriatic arthritis Blocks TNF-a | Adalimumab |
Tx: Crohn’s TNF-a blocker Pt has tuberculosis recurrence | Infliximab |
Tx: RA IL-1 blocker | anakinra |
Broad immunosuppression for acute kidney transplant rejection Causes cytokine release syndrome, Rabbit | ATG |
Broad immunosuppression for acute kidney transplant rejection Causes cytokine release syndrome, mouse | OKT3 |
B-Cell targeters Tx: CD20+ non-H Lymphoma & 2nd ary treatment for RA when TNF-a inhibitors fail | Rituximab |
Only targets activated T cells given prophylactically for Kidney transplant | Daclizumab |
Treats B-cell chronic lymphocytic leukemia | Alemtuzumab |
Tx; Plaque psoriasis w/ months of relief after discontinued SE; dose dependent CD4/8 depletion and skin cancer CI:HIV | Alefacept |
This and TNF-a or anikinra leads to sure infection | Abatacept |
2ndary treatment of RA when TNF-a inhibitors or methotrexate doesn’t work causing T-cell anergy | Abatacept |
Tx: Chronic plaque psoriasis SE: immune mediated:thrombocytopenia, hemolytic anemia. Symptoms return immediately after stopped | efalizumab |
Treats MS but can cause Progressive multifocal leukoencephalopathy caused by JC virus | Natalizumab |
Created by:
csheck
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