DCPA Gout Pharm Word Scramble
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| Question | Answer |
| Gout S&S | Sudden Onset. Monarticular - most common = MTP. Familial & associated with foods & drinks high in Purines (ETOH). Tophus - Crystals in joint. High Uric Acid level (Metabolic-overproduction or renal - underexcretion) |
| Gout Tx - Acute Arthritis | NSAIDs (Indocin &/or COX-2 Inhibitor), Colchicine, Steroirds, Opiod & Bed Rest |
| Gout Tx - Hyperuricemia | Colchicine, Probenecid & allopurinol |
| Gout Type - Metabolic | Overproducer > 800mg uric acid in urine |
| Gout Type - Renal | Underexcretion < 800 mg uric acid in urine |
| Colchicine MOA | Decreases leukocyte motility, phagocytosis, & deposition of uric acid in joints. |
| Colchicine Pregnancy Category | C |
| Colchicine Response time | 24-48 hours - oral & 6-12 hours IV. |
| Colchicine Contraindications | Liver or Renal Dz. |
| Colchicine SE | N/V, anorexia, diarrhea & allopecia |
| Colchicine decrease absorption... | B12 |
| Colchicine avoid... | Alcohol & ASA |
| Probenecid | Benemid, Probalan |
| Probenecid (Benemid, Probalan) MOA | Inhibits reabsorption of uric acid = increased excretion. |
| Probenecid (Benemid, Probalan) Form & Onset | Tablet - 2 hours |
| Probenecid (Benemid, Probalan) Contraindications | Children < 2 y.o., uric acid stones, Creatinine > 2mg/dl. |
| Probenecid (Benemid, Probalan) Pregnancy Category | B |
| Probenecid (Benemid, Probalan) SE | HA, Fever, Anorexia, Flushing, Itching, Renal Calculi & Leukopenia |
| Probenecid (Benemid, Probalan)avoid | DM, ASA, PCN (penicillin) & Indocin |
| Allopurinol | Zyloprim |
| Allopurinol (Zyloprim) MOA | Inhibits Xanthine Oxidase - decrease uric acid production (Reduces uric acid without affecting purines & DNA synthesis) |
| Allopurinol (Zyloprim) Contraindications | Acute gouty attack, allergy, pregnancy & lactation |
| Allopurinol (Zyloprim) Pregnancy Category | C |
| Allopurinol (Zyloprim) Form & Onset | Tablet: 1-2 days |
| Allopurinol (Zyloprim) SE | Pruritic Rash, Vasculitis, hepatitis & drug rash with ampicillin. Drowsiness |
| Allopurinol (Zyloprim) affected by... | alcohol decreases the effectivness |
| Febuxostat | Uloric |
| Febuxostat (Uloric) MOA | Inhibits Xanthine Oxidase - decrease uric acid production (Reduces uric acid without affecting purines & DNA synthesis) |
| Febuxostat (Uloric) Initially Response | Increase gout flare ups |
| Febuxostat (Uloric) SE | Cardiac/thrombolitic events, increases LFTs, Nausea & Rash |
| Febuxostat (Uloric) Pro vs. Allopurinol (Zyloprim) | Less DI - None with Warfarin |
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