Lung Tmt Word Scramble
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Question | Answer |
Tmt for NSCLC (non-small cell lung carcinoma) ? | * based on receptor mutations in ALK, ROS1, and EGFR |
If no mutations ? | * Systemic cytotoxic chemotherapy ...... * Cisplatin or carboplatin based regimen often in combination with bevacizumab |
Nomenclature... “mab” ? | * monoclonal antibodies |
“ximab” ? | * chimeric monoclonal antibodies |
“mumab” ? | * humanized monoclonal antibodies |
“tinib” ? | * tyrosine kinase inhibitors |
“zomib” ? | * proteasome inhibitors |
Bevacizumab ? | * Targets all forms of vascular endothelial growth factor A (VEGF-A), which prevents vascular proliferation |
Bevacizumab Side Effects ? | * Black Box for GI perforations and Hemorrhaging..... can also cause thrombuses, HF, HTN, Necrotizing Fascitis |
Erlotinib ? | * Use: NSCLC--First-line therapy in patients with EGFR mutations..... * Tyrosine Kinase Inhibitor--- Selectively and reversibly inhibits the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) |
Erlotinib Side Effects ? | * Pulmonary issues, skin blistering, diarrhea, and eye issues |
Crizotinib ? | * Use: metastatic NSCLC ----for anaplastic lymphoma kinase (ALK)-positive tumors..... * Tyrosine Kinase Inhibitor |
Crizotinib Side Effects ? | * Bradycardia, hepatotoxicity, occular toxicity, pulmonary issues and Prolong QT interval |
Created by:
thamrick800
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