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Lung Tmt

Therapy for Lung/Pleura Tumors

Tmt for NSCLC (non-small cell lung carcinoma) ? * based on receptor mutations in ALK, ROS1, and EGFR
If no mutations ? * Systemic cytotoxic chemotherapy ...... * Cisplatin or carboplatin based regimen often in combination with bevacizumab
Nomenclature... “mab” ? * monoclonal antibodies
“ximab” ? * chimeric monoclonal antibodies
“mumab” ? * humanized monoclonal antibodies
“tinib” ? * tyrosine kinase inhibitors
“zomib” ? * proteasome inhibitors
Bevacizumab ? * Targets all forms of vascular endothelial growth factor A (VEGF-A), which prevents vascular proliferation
Bevacizumab Side Effects ? * Black Box for GI perforations and Hemorrhaging..... can also cause thrombuses, HF, HTN, Necrotizing Fascitis
Erlotinib ? * Use: NSCLC--First-line therapy in patients with EGFR mutations..... * Tyrosine Kinase Inhibitor--- Selectively and reversibly inhibits the tyrosine kinase activity of the epidermal growth factor receptor (EGFR)
Erlotinib Side Effects ? * Pulmonary issues, skin blistering, diarrhea, and eye issues
Crizotinib ? * Use: metastatic NSCLC ----for anaplastic lymphoma kinase (ALK)-positive tumors..... * Tyrosine Kinase Inhibitor
Crizotinib Side Effects ? * Bradycardia, hepatotoxicity, occular toxicity, pulmonary issues and Prolong QT interval
Created by: thamrick800