LECOm Pharm Ch 20 Volume Regulation
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| (1) ACE-I given as an active drug with active metabolite | captopril
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| (2) ACE-I given as ester prodrug converted to active metabolite | enalapril and ramipril
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| (1) ACE-I given as active drug, excreted unchanged | lisinopril
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| Class causing angioedema, agranulocytosis, neutropenia | ACE inhibitors
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| 2 classes used in diabetic neuropathy | ACE-I and AT2 R antagonist
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| Class that can cause rhabdo-, angioedema and rare thrombocytopenia | AT-II R blockers
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| Used in Acutely decompensated heart failure | nesiritide
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| BNP analogue | nesiritide
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| Nesiritide with an ACE inhibitor can cause | severe hypotension
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| Used in SIADH, ADPCKD, and Euvolemic hyponatremia, can cause afib | conivaptan
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| MOA of acetazolamide | CA 2 and 4 inhibitor
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| Can be used in glaucoma | acetazolamide
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| Used as 1st line for edema states | loop diuretics
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| Most potent loop diuretic | bumetanide
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| Used to treat hyper-calcemic and kalemic states | loop diuretics
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| Diuretics help treat hypercalcinuria | Thiazides
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| Diuretics useful with renal cysts? | -vaptans
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| Diuretics that help treat calcium wasting in osteoporosis? | Thiazides
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| Loop diuretic that can be used in Pt’s with sulfa allergy | ethycrinic acid
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| 2 Diuretic used for primary aldosteronism? | spironolactone and eplerone
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| Diuretic that may uncover diabetes in a Pt? | HCTZ
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| Diuretic that may induce hypernatremia? | mannitol
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| 4 diuretics acting in the collecting duct | spirinalactone, eplernone, Amiloride, triamterene
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| 2 Diuretic the inhibits myocardial fibrosis? | spirinilactone, eplernone
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| 2 Diuretics used to treat Liddle Syndrome | amiloride and triampterine
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| Diuretic used in nephrogenic diabetes insipidus? | thiazides
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| Diuretic used to treat glaucoma, mountain sickness, and gout? | acetazolamide
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| What type of diuretic can cause hyperkalemia and hyperkalemic metabolic acidosis | potassium sparing
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| Which diuretics are potassium sparing | spironolactone, eplernone, amiloride, triamterene
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| MOA of Amiloride and triamterene | inhibit ENaC in collecting ducts
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| DOC for ascites and edema due to decreased plasma protein/hepatic failure? | spironolactone and eplerenone
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| Diuretic that can cause torsade de pointes? | Thiazides
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