LECOm Pharm Ch 33 Abx Cell Wall Synthesis
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| PEP analogues that inhibit bacterial enol pyruvate tranferase (2) | fosfomycin, fosmidomycin
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| 2 drugs used to treat gram neg. UTIs i.e. E.coli, Klebsiella, Serratia, Clostridia | fosfomycin, fosmidomycin
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| Used to treat m.tuberculosis, M.avium complex and can cause seizures | cycloserine
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| Used for skin and eye infections, or to irradicate C.diff or VRE, but not absorbed systemically | bacitracin
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| Used to treat MRSA or C.diff, can cause neutropenia, ototoxicity, nephrotoxicity or Red Man syndrome | Vancomycin
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| Penicillin can cause (8) | seizure, C.diff, drug-induced eosinophilia, hemolytic anemia, neuropathy, acute interstitial nephritis, anaphylaxis
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| 5 beta lactam resistant Penicillins and what they treat | Oxacillin, Cloxacillin, Dicloxacillin, Nafcillin, Methicillin; skin and soft tissue Infx and MRSA
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| Treat invasive enterococcal Infx or Listeria meningitis with | ampicillin
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| Use amoxicillin for | ENT, dental and endocarditis prophylaxis
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| 4 penicillin based drugs used for P.aeruginosa or hospital-aquired gram negative pneumonia | Carbacillin, Ticarcillin, Piperacillin, Mezclocillin
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| Over view of cephalosporin 1st-3rd gen coverage of Gram positive/neg | increased in Gram negative coverage from 1-3 and decrease in gram positive coverage in 1-3
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| 1st gen cephalosporins (2) and what they treat | cefazolin and cephalexin; proteus, e.coli, klebsiella, skin soft tissue, surgical prophylaxis; good gram +
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| 4 SE of 1st gen cephalosporins | C.diff, leukopenia, thrombocytopenia, hepatotoxicity
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| 2nd gen ceph.. used for community acquired pneumonia | cefuroxime
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| 2nd gen ceph (2) used for intra abdominal and pelvic infxs | Cefotetan and Cefoxitin
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| Highest CNS penetration of the cephalosporins | 3rd gen
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| 3rd gen cephalosporin that may cause cholestatic hepatitis | ceftriaxone
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| 2nd and 3rd gen ceph that can cause disulfiram like reaction | cefotetan and cefoperazone
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| Cephalosporin that can cause production or erythrocyte Ab with little hemolysis | cefepime
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| Used for gram negative coverage w/ PCN allergy | aztreonam
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| High levels of this drug, caused by taking probenecid can lead to seizures | meropenem
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| Used against mycobacterium and can cause Optic neuritis, blindness, peripheral neuropathy, neutron/thrombocytopenia | ethambutol
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| Do not take this anti-mycobacterium drug with antacids | ethambutol
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| The mycobacterium drug can cause anemia and hepatotoxicity and shouldn’t be used in gouty Pt’s | pyrazinamide
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| Neurotoxicity of this anti-mycobacterial drug can be prevented by co-administering pyridoxine | isoniazid
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| 2 drugs causing hepatitis, neurotoxicity, SLE, seizure, and hematological abnormalities | Isoniazid and ethionamide
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