LECOM Pharm Ch 36 Anti-virals
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| Inhibitor of viral attachment and entry | enfirvutide T-20
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| This drug used to limit the spread of HIV can cause Guillain-Barre syndrome | enfirvutide
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| These drugs prevent Influenza A from uncoating | amantadine and rimantadine
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| DOC for Infuenza A prophylaxis in nursing homes | rimantadine
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| Nucleoside analogues are used with these 5 viruses | HIV, HBV, HSV, VZV, CMV
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| Selectivity of acyclovir | HSV and VZV thymidine kinases phosphoralates ACV more effectively than human enzymes
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| Acyclovir is used to treat | HSV and VZV
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| More effective but less selective than acyclovir for HSZ and VZV | Famciclovir and pnciclovir
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| This drug comes as an ointment that treats cold-sores cause by HSV | penciclovir
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| Resistance to acyclovir is cause d by | mutations in TK gene or DNA polymerase gene
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| Used to treat serious CMV infections | gancyclovir
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| Drug used to treat CMV retinitis and the drug that needs to be given with it | cidofovir and probenacid
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| Magor side effect of Cidofovir | nephrotoxicity
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| Anti-HIV nucleotide analogue drug given once daily | tenofovir
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| Anti-HBV nucleotide analogue | Adefovir
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| Anti-HIV nucleoside analogue that accumulates in all cells with the least toxicity | Lamivudine 3TC
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| Lamivudine (3TC) can be used to treat what? | HIV and chronic HBV with active replication[
Anti-HIV nucleoside analogue with little side effects and once daily dosing
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| Used to treat serious HSV and CMV infections resistant to acyclovir and gancyclovir | foscarnet
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| Major dose limiting toxicity of foscarnet | renal impairment
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| First anti-HIV drug to be taken once daily | efivirenz
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| HIV Tx, pill containing these 3 drugs approved for once daily treatment | efavirenz, tenofovir, and FTC (emtricitabine)
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| 3 NNRTIs and their main downside to HIV treatment | efevirenz, nevirapin, delavirdine; rapid resistance when given alone
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| Class of drugs that allows HIV viral particles to bud but they are immature and noninfectious | HIV protease inhibitors more –navir’s
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| MOA of oseltamivir and zanamivir | prevents neuraminidase cleavage of influenza virus tethers
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| Used as prophylactic treatment of Influenza A and B | oseltamivir
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| Used intravitreally to treat CMV retinitis | fomivirsen
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| DOC for RSV | ribavirin aerosol
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| Used to treat chronic HCV with addition of an interferon | ribavirin
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| Used to prevent RSV in high risk children | palivizumab
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| Used to treat MS | interferon-β
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| Used to treat HCV, HBV, Kaposi Sarcoma, CML, hairy cell leukemia | Interferon-α
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| Used to treat HPV, basal cell carcinoma, actinic keratosis | imiquimod
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| Used to treat HIV and causes dyslipidemia | any of the –navir’s
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| Drug that can induce HUS | acyclovir
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| Can cause metabolic acidosis and decreased intraocular pressure | cidofovir
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| Treats HSV and can cause seizures | Foscarnet
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| Can cause gastric bleeding and aplastic anemia | interferon-α
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| *DOC for influenza A | *amantadine , rimantadine
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| *DOC for RSV | *Ribavirin
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| DOC for CMV retinitis; not intravitreal | Val/Gancyclovir
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| SE for ganciclovir | Neutro, leuko and thrombocytopenia, anemia
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| HIV antiviral class known to have severe drug interactions by causing inhibition of metabolism | protease inhibitors
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| HIV med used to reduce transmission during birth | zidovudine AZT
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| DOC for herpes and its MOA | Acyclovir and inhibits thymidine kinase (DNA polymerase in book)
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