LECOM Pharm Ch 34 antifungals
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| MOA of flucytosine | inhibits fungal DNA synthesis. As 5-FU
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| Flucytosine should be used with caution in these Pts | renal Pts
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| Concaminant use of amphotericin and this drug results in killing of Aspergillus | Flucytosine
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| Treats candidiasis, Cryptococcosis, Chromomycosis | Flucytosine
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| Use this to treat fungal Infx of the skin, hair and nails, and must be given until infected tissues are completely replaced | Griseofulvin
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| Use to treat Trichophyton, Microsporum, or epidermophyton | Griseofulvin
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| Concurrent treatment with barbiturates decreases Gi absorbance | Griseofulvin
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| Anti-fungal medication that induces P450 enzymes | griseofulvin
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| This drug taken orally can exacerbate psoriasis or subacute cutaneous lupes erythematosus | Oral terbinafine
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| MOA of Terbinafine and drug class | inhibit squalene epoxidase; allylamines
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| MOA of Naftifine and drug class | inhibits squalene epoxidase; allylamines
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| MOA of Butenafine and drug class | inhibits squalene epoxidase; benzylamine
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| 3 topical drugs more effective against common dermatophytes than azole | Terbinafine, Naftifine, butenafine
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| This is used to treat onychomycosis | terbinafine
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| Squalene epoxidase inhibitor available only in topical cream or gel | Naftifine
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| Terbinafine is not recommended for use in these 3 Pt groups | liver and kidney damage, pregnant women
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| This drug can be used to treat onychomycosis, but has varied oral availability so IV doses are used | itraconazole
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| These anti-fungals inhibit P450 3A4 | itraconazole, voriconazole, and fluconazole
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| 5 triazoles | Flu-, Itra-, Posa-, Ter-, Vori- conazoles
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| Ketoconazole cannot be used in Pt’s with achlorhydria, or use of drugs lowering stomache pH | ketoconazole
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| Anti-Fungal agent used for inhibition of all gonadal and adrenal steroids | Ketoconazole
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| MOA of azoles | inhibits 14α-sterol demethylase
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| This imidazole drug also affects fungal fatty acid synthesis | miconazole
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| Pt is allergic to sulfites, what topical azole should not be used | ketoconazole
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| Major adverse effect in itraconazole use | hepatotoxicity
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| Triazole that has potent effects on aspergillus and Zygomycetes | posaconazole
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| Triazole thathas almost 100% Bio-availability orally, is not influenced by stomach pH, and penetrates CSF, sputum, urine and saliva | fluconazole
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| DOC for systemic candidiasis and cryptococcal meningitis | fluconazole
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| DOC for cooccidioidal meningitis | fluconazole
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| In blastomycosis, histoplasmosis, and sporotrichosis which do you use? Itraconazole or fluconazole? | itraconazole, more active
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| Pathway of fluconazole resistant candida | P450 enzyme mutations, multidrug efflux transporter proteins
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| DOC for invasive aspergillosis, fusarium, scedusporium | voriconazole
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| Pt c/o strange symptoms such as photophobia and seeing colored lights after being started on a new drug. What is it? | voriconazole
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| This drug should not be used in renal secondary to increased CNS toxicity of an accumulating metabolite | voriconazole
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| Vaginal suppository inserted at bedtime to treat vaginal candidiasis | Terconazole
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| MOA of Echinocandins | non-competatively inhibit β-(1,3)- D-glucan synthesis
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| Used as primary therapy for esophageal candidiasis and candidemia | Caspofungin
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| Used as salvage therapy for Aspergillus Infx and as empiric therapy for febrile neutropenia | caspofungin
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| These 3 drugs can cause puritis and rash secondary to histamine release | caspo-, mica-, anidula-, -fungins
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| This is used as antifungal prophylaxis for hematopoietic stem cell transplant recipients | micafungin
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