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LECOM Pharm Ch 11 GABA

Quiz yourself by thinking what should be in each of the black spaces below before clicking on it to display the answer.
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Question
Answer
Inhibits GAT-1   Tiagabine  
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Inhibits GABA-T   vigabatrin  
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Midazolam MOA and Duration   Benzo; potentiate GABA & Short  
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Chlorazepate MOA and Duration   Benzo; potentiate GABA & Short  
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Triazolam MOA and Duration   Benzo; potentiate GABA & Short  
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Zolpidem MOA and Duration   Benzo; potentiate GABA & Short  
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Alprazolam MOA and Duration   Benzo; potentiate GABA & Intermediate  
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Lorazepam MOA and Duration   Benzo; potentiate GABA & Intermediate  
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Estazolam MOA and Duration   Benzo; potentiate GABA & Intermediate  
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Temazapam MOA and Duration   Benzo; potentiate GABA & Intermediate  
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Chlordiazepoxide MOA and Duration   Benzo; potentiate GABA & Long  
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Clonazepam MOA and Duration   Benzo; potentiate GABA & Long  
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Diazepam MOA and Duration   Benzo; potentiate GABA & Long  
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Flurazepam MOA and Duration   Benzo; potentiate GABA & Long  
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Quazepam MOA and Duration   Benzo; potentiate GABA & Long  
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Short acting benzo that treats insomnia   triazolam  
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(2) intermediate acting benzos that treat insomnia   estazolam and temazapam  
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(2) long acting benzos used for insomnia Tx   Flurazepam and Quazepam  
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Short acting Benzo used with Pre- anesthetic   midazolam  
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(2) long acting benzo’s used for anxiety   chlordiazepoxide and Diazepam  
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Benzo used for insomnia with decreased muscle relaxant/anxiolytic action   Zolpidem  
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Fast onset benzo for insomnia used intermittently   Triazolam  
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Long acting benzo used as a muscle relaxant   Diazepam  
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MOA of barbituates   increases time Cl- channels stay open  
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2 ultra-short acting Barbs   Thiopental and Methohexital  
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3 short acting Barbs   Pento- Seco-, Amo-barbital  
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Long acting Barb   Phenobarbital  
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Long acting barbiturate that undergoes hepatic and renal clearance   phenobarbital  
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Used as single bolus injection for rapid anesthesia   etomidate  
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Used for rapid or prolonged anesthesia, commonly leads to cardiovascular depression   propofol  
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Used to treat spasticity; oral or intrathecally   Baclofen  
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Used in ALS treatment   Riluzole  
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Slows Alzheimer’s disease   memantine  
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Used with Levadopa for treatment of Parkinson’s dyskinesia   amantadine  
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Long acting benzo used for seizures   Clonazepam  
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Used to reverse benzo’s   Flumazenil  
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3 benzos used IV for general anesthesia   Midazolam, Lorazepam, Diazepam  
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Benzo with less rebound insomnia   Flurazepam  
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2 ultra-short acting drugs used to induce anesthesia by prolonging the time Cl- channels are open   thiopental and Methohexital  
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Benzo that can be absorbed transmucosally   methohexital  
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Treats raised intracranial pressure by prolonging the time Cl-channels are open   thiopental  
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