List of HIV Medication Resistance Mutations
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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| TAMS - meds to cause | ZDV, D4T
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| TAMS (6 of them) name worst 3 | L210W, T215Y/F, M41L
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| TAMS- what they do | Confers cross-resistance to all nRTIs
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| M184V- meds that cause | 3TC, FTC,>> ABC, DDI
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| M184V- meds that are lost | Loss of 3TC, FTC>> low level R to ABC
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| M184 V- Meds hypersensitive | ZDV, D4T, TDF,
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| M184V- Good things it does | impaired viral fitness, increased RT fidelity, Slows TAMS
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| K65R- meds causing | TDF (signature), ABC, DDI, FTC, 3TC, D4T
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| K65R-Meds lost | TDF, ABC, DDI, FTC, 3TC
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| K65R- Meds hypersensitive | Increases ZDV
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| L74V- Meds causing | ABC, DDI
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| L74V- Meds lost | Loss of ABC, DDI
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| L74V- Meds hypersensitized | Increases ZDV, TDF
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| Q151 complex- Meds causing | ZDV/ DDI
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| Q151 complex- Meds lost | Resistance to nRTIs except TDF
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| T69 insertion | Resistance to ALL nRTIs
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| K103N- Meds causing | All NNRTIs
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| K103N- Meds lost | All NNRTIs
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| Y181C- Meds causing | NVP
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| Y181C- Meds lost | Low-level cross R to NNRTIs
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| 46IL, 82AFTS, 84V, 90M | Multiple PI resistance when >4
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| 36DS, 37V, 39R, 42T, 43D | Enfuvertide- R in the gp41 envelope from 36-45
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