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HIV Resist Mutations
List of HIV Medication Resistance Mutations
Question | Answer |
---|---|
TAMS - meds to cause | ZDV, D4T |
TAMS (6 of them) name worst 3 | L210W, T215Y/F, M41L |
TAMS- what they do | Confers cross-resistance to all nRTIs |
M184V- meds that cause | 3TC, FTC,>> ABC, DDI |
M184V- meds that are lost | Loss of 3TC, FTC>> low level R to ABC |
M184 V- Meds hypersensitive | ZDV, D4T, TDF, |
M184V- Good things it does | impaired viral fitness, increased RT fidelity, Slows TAMS |
K65R- meds causing | TDF (signature), ABC, DDI, FTC, 3TC, D4T |
K65R-Meds lost | TDF, ABC, DDI, FTC, 3TC |
K65R- Meds hypersensitive | Increases ZDV |
L74V- Meds causing | ABC, DDI |
L74V- Meds lost | Loss of ABC, DDI |
L74V- Meds hypersensitized | Increases ZDV, TDF |
Q151 complex- Meds causing | ZDV/ DDI |
Q151 complex- Meds lost | Resistance to nRTIs except TDF |
T69 insertion | Resistance to ALL nRTIs |
K103N- Meds causing | All NNRTIs |
K103N- Meds lost | All NNRTIs |
Y181C- Meds causing | NVP |
Y181C- Meds lost | Low-level cross R to NNRTIs |
46IL, 82AFTS, 84V, 90M | Multiple PI resistance when >4 |
36DS, 37V, 39R, 42T, 43D | Enfuvertide- R in the gp41 envelope from 36-45 |