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HIV Resist Mutations

List of HIV Medication Resistance Mutations

TAMS - meds to cause ZDV, D4T
TAMS (6 of them) name worst 3 L210W, T215Y/F, M41L
TAMS- what they do Confers cross-resistance to all nRTIs
M184V- meds that cause 3TC, FTC,>> ABC, DDI
M184V- meds that are lost Loss of 3TC, FTC>> low level R to ABC
M184 V- Meds hypersensitive ZDV, D4T, TDF,
M184V- Good things it does impaired viral fitness, increased RT fidelity, Slows TAMS
K65R- meds causing TDF (signature), ABC, DDI, FTC, 3TC, D4T
K65R-Meds lost TDF, ABC, DDI, FTC, 3TC
K65R- Meds hypersensitive Increases ZDV
L74V- Meds causing ABC, DDI
L74V- Meds lost Loss of ABC, DDI
L74V- Meds hypersensitized Increases ZDV, TDF
Q151 complex- Meds causing ZDV/ DDI
Q151 complex- Meds lost Resistance to nRTIs except TDF
T69 insertion Resistance to ALL nRTIs
K103N- Meds causing All NNRTIs
K103N- Meds lost All NNRTIs
Y181C- Meds causing NVP
Y181C- Meds lost Low-level cross R to NNRTIs
46IL, 82AFTS, 84V, 90M Multiple PI resistance when >4
36DS, 37V, 39R, 42T, 43D Enfuvertide- R in the gp41 envelope from 36-45
Created by: ROBE2956