Pharm 44 Immuno suppression LECOM
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| Azathioprine AZA Class? | Cytotoxic- Antimetabolite
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| Methotrexate MTX Class? | Cytotoxic- Antimetabolite
Mycophenolic Acid Class ?
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| Mycophenolate Mofetil Class ? | Cytotoxic- Antimetabolite
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| Leflunomide Class? | Cytotoxic – Antimetabolite
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| Use in Renal transplant, IBS, and RA. Causes pancreatitis and hepatotoxicity | Azathiprene
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| Use in tumors, autoimmune. Folate analogue inhibits DHFR | methotrexate
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| Cyclophosphamide Class? | Alkylating agent
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| Used almost exclusively with SLE or xenotransplants. Causes bladder cancer | cyclophosphamide
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| Used to prevents cyclophosphamide bladder cancer | mesna
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| Don’t give oral iron with this drug | Mycophenolate mofetil
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| (2) Can cause GI bleed, lymphoma. Tx: solid organ, lupus nephritis, RA, Pemphigus | Mycophen-olic acid /-olate mefetil
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| Tx: RA Hepatotoxic (long action). Causes lung disease CI:Pregnancy | leflunomide
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| Adverse Effects: interstitial fibrosis, nephrotoxic, HTN, HCh, hepatotoxic | cyclosporine
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| Tx: chronic dry eyes, organ transplant, RA, psoriasis. MOA: inhibits IL-2 release | cyclosporine
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| Tx: organ transplant, atopic dermatitis SE: nephron, htn, prolong QT | Tacrolimus
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| This is incorporated into coronary stents to prevent coronary artery smooth muscle proliferation | Sirolimus
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| Tx: Organ transplant No nephrotoxicity SE: HTN, HLip, thrombocytopenia | Sirolimus
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| Can cause demyelinating disease of CNS Tx: Psoriatic arthritis Blocks TNF- a & b | Etanercept
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| Can cause demyelinating disease of CNS Tx: Psoriatic arthritis Blocks TNF-a | Adalimumab
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| Tx: Crohn’s TNF-a blocker Pt has tuberculosis recurrence | Infliximab
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| Tx: RA IL-1 blocker | anakinra
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| Broad immunosuppression for acute kidney transplant rejection Causes cytokine release syndrome, Rabbit | ATG
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| Broad immunosuppression for acute kidney transplant rejection Causes cytokine release syndrome, mouse | OKT3
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| B-Cell targeters Tx: CD20+ non-H Lymphoma & 2nd ary treatment for RA when TNF-a inhibitors fail | Rituximab
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| Only targets activated T cells given prophylactically for Kidney transplant | Daclizumab
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| Treats B-cell chronic lymphocytic leukemia | Alemtuzumab
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| Tx; Plaque psoriasis w/ months of relief after discontinued SE; dose dependent CD4/8 depletion and skin cancer CI:HIV | Alefacept
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| This and TNF-a or anikinra leads to sure infection | Abatacept
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| 2ndary treatment of RA when TNF-a inhibitors or methotrexate doesn’t work causing T-cell anergy | Abatacept
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| Tx: Chronic plaque psoriasis SE: immune mediated:thrombocytopenia, hemolytic anemia. Symptoms return immediately after stopped | efalizumab
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| Treats MS but can cause Progressive multifocal leukoencephalopathy caused by JC virus | Natalizumab
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