Pharm II - Spring 2012
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| Acetaminophen trade name | Tylenol
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| Dosing of acetaminophen | 325-650mg q4-6 hrs
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| AEs of APAP? | Usu well-tol, hepatotox w/ OD or chronic high doses, nephropathy, anemia, blood dyscrasias
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| CI for APAP? | Severe hepatic impairment/active liver dz
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| Trade name ibuprofen? | Advil, Motrin
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| Dosing of ibuprofen? | 200-400mg q4-6hrs PO; 400-800mg q6hr IV
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| Ibuprofen AEs? | GI, renal, hematologic, hrt, hepatic, CNS
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| CIs for ibuprofen | Angioedema, bronchospasm w/ ASA or other NSAID; 3rd trimester preg
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| What can occur if ibuprofen/celebrex taken in 3rd trimester of preg? | Premature closure of ductus
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| Trade name of celecoxib? | Celebrex
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| Dosing of celecoxib? | 100 bid or 200mg qday for OA; 100-200mg bid for RA
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| AEs of celecoxib? | Less GI tox, potential for incrsd risk of heart events, renal, hepatic
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| CIs of celecoxib? | Allergy to sulfa-containing produx or ASA or other NSAIDS; 3rd trimester preg
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| Trade name of hydrocodone/APAP? | Vicodin, Lortab
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| Which class is vicodin? | C-III
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| What is the term used to refer to a med related to morphine? | Phenanthrene
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| Dosing for hydrocodone/APAP? | 1-2 PO q4-6hrs prn (5/500)
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| Max/day of hydrocodone/APAP? | 8/day
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| AEs of vicodin? | Drowsiness, N/V/C, pruritis
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| CIs for vicodin? | CYP3A4 substrate = can reach toxic levels w/ macrolides, ketoconazole, protease inhibs
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| Trade name of Tramadol? | Ultram
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| Class of Tramadol? | C-IV
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| Dosing of Tramadol? | 50-100mg q4-6hrs PO
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| Tramadol max/day? | 4g/day or >75yo = 3g/day
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| Onset of action for tramadol? | ~1hr
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| Pt w/ low CrCl taking vicodin..what is the max/day? | 2g/day
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| AEs of tramadol? | Drowsiness, N/V/C, pruritis
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| CIs with tramadol? | Sz d/o, anti-depress, anti-psychotic, w/macrolides, ketoconazole, protease inhibs (CYP3A4 substrate)
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| Naloxone trade name? | Narcan
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| Category of Naloxone? | Mu-ANTagonist
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| Use of narcan? | OD reversal
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| Dosing of narcan? | 0.4-1.2mg IV (onset ~2min)...may need to repeat q2-3mins
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| AE's of narcan? | Syncope, HA, insomnia, dizziness, N/V, injex site rxn
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| CI's of narcan? | Acute hepatitis, liver failure
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| Methotrexate trade name? | Rheumatrex
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| Methotrexate category? | Non-biologic DMARD
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| What does DMARD stand for? | Dz-mod anti-rheu drug
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| Gold std for RA? | Methotrexate
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| Use of methotrexate? | More severe/active RA
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| Dosing of methotrexate? | 7.5-20 mg/WEEK PO or Injex
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| Clin response of Methotrexate? | 1-2 months
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| AEs of methotrxate? | Stomatitis (inflamm of mucus membranes), nausea, diarrhea, alopecia, elevated LFTs, liver tox, thrombocytopenia, leukopenia, rare pulmonary and lymphproliferative tox
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| How can you possibly prevent alopecia with methotraxate use? | Concurrent use of folic acid
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| CI for methotrexate? | Preg or nursing, liver dz, kidney impairment, sig lung dz, alcohol abuse
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| What should be monitored with Methotrexate? | CBC, LFTs
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| If consumed in excess, what may decrs effectiveness of methotrexate? | Caffiene >180mg/day
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| Trade name of Hydroxychloroquine? | Plaquenil
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| AEs of Hydroxychlor? | Rash, diarrhea, abd cramps, retinal tox w/ high doses
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| What needs to be done periodically with those on Hydroxychlor? | Ophthalmic exams
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| CIs of hydroxychlor? | Long-term use in kids
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| Trade name of Etanercept? | Enbrel
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| Etanercept is what category? | Biolog-DMARD: Anti-TNF-alpha (used as monotherapy)
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| AEs of Etanercept? | HA, abd pain, resp tract infex, rhinitis, infex, lymphomas, may exacerbate or cause HF (WATCH FOR INFECTIONS!)
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| Prednisone trade name? | PredniSONE Intensol
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| Dosing for prednisone? | <7.5mg/day
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| AEs of prednisone? | HTN, hyperglycemia, cataracts, skin fragility, fluid retntion, wt gain, osteoporosis
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| CIs for prednisone? | Systemic fungal infex, admin of live or live-attentuated vaccines
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