Cell-Mediated Immune Responses
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| ANTIGEN BOUND TO MHC MOLECULES | MHC MOLECULES
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| Where would you find MHC Class I molecules? | They're on all cells, EXCEPT RBC
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| How do Class I molecules present antigen? When? | They present antigen from INSIDE the cell in an INFECTION
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| Where would you find MHC Class II antigens? From where do they come? | On some leukocytes; come from OUTSIDE a cell
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| What are the MHC Class II antigens? | B-cells, macrophages, and dendridic cells
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| ORIGIN OF T-CELLS | T-CELLS COME ABOUT
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| Where do t-cells get created? | Bone marrow
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| Where are they processed? | In the Thymus
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| What are the two steps inovolved with thymus processing? | Clonal expansion of cells reacting with MHC molecules and elimination of cells recognizing self
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| Why can't we make T-cells when we're older? | Because the thymus decreases in size, so no more new t-cells
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| Where do b and T cells go after they've matured in the bone marrow and thymus, respectively? | Go to spleen and lymph nodes
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| RESPONSE TO ANTIGEN | RESPONSE TO ANTIGEN
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| HELPER T-CELLS | HELPER T-CELLS
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| What is the T cell receptor for antigen? | MHC
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| What kind of a marker do helper t-cells have? | A protein CD4 marker
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| What is the purpose of the maker? | The marker is what sticks to the MHC Class II molecules
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| What does the first do? | Interacts with MACROPHAGES to activate them
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| What does the second do? | Interacts with B-CELLS to activate antibody response and, thus, formation of B-memory cells
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| CYTOTOXIC T-CELLS | KILLER T-CELLS
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| What kind of TCR do they need to be presented with? | MHC Class I
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| What kind of a marker do cytotoxic t-cells have? | A CD8 Protein
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| EVENTS IN RESPONSE TO ANTIGEN | I SAW AN ANTIGEN, NOW WHAT?
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| What are the seven steps involved in this response? | 1. Antigen presenting cells interact with antigen 2. APC go to lymph nodes 3. APC present antigen 4. Activate T-cell clones 5. Clonal explansion of T-cells 6. Immune T-cells return to circulation 7. Helper T-cells or C-T cells do stuff
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| CLONAL EXPANSION OF T-CELLS | Various responses described
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| What are Th1 cells? What are they fighting./what do they do? | Macrophage killing cells that help out CT cells
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| Whare are TH2 cells? What are they fighting? | Activate antibody response to rid of viruses
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| HELPER T-CELL ACTIVATION | HELPTER T-CELL ACTIVATION
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| What do helper t-cells activate? | macrophages and B-cells
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| Can you have unactivated macrophages? | Yeah, but they're not as good
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| Which type of T-cell function is most important to get a type I allergic response? | TH2 response
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| MECHANISM OF CELL ACTIVATION | CELL ACTIVATION STEPS
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| What does IL-1 activate? | lymphocytes
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| What does IL-2 activate? ANd what does the thing it activates requre activation by? | Role with T-cells
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| What does IL-8 activate? What does the thing it activates have a role with? | Neutrophils have a role in Chemotaxis
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| What does IL-12 activate? | Helpter T-cells
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| What are some examples of those cells? | Macrophages, CD8 T-cells, and NK cells
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| What is the function of TH2 cells? | Stimulates production of eosinophils, IgM, and IgE
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| Function of CT Cells? | Destroys target cells on contact
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| Function of Regulatory T cells? | Regulates immune response and helps maintain tolerance
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| Function of activated macrophages? | Better phagocytic activity to attack cancer cells
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| SUMMARY FUNCTIONS | SUMMARY FUNCTIONS
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| IL-2 | Role with T-cells
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| IL-8 | Chemotaxis for immune system cells and phagocytes to inflammation site
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| What induces a TH2? Th1> | TH2--B-cells; TH1-Macrophages
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| T independent antigens have what characteristics? | They have repeating antigens that activate B-cells to make Ab
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