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MICRO3
Cell-Mediated Immune Responses
| Question | Answer |
|---|---|
| ANTIGEN BOUND TO MHC MOLECULES | MHC MOLECULES |
| Where would you find MHC Class I molecules? | They're on all cells, EXCEPT RBC |
| How do Class I molecules present antigen? When? | They present antigen from INSIDE the cell in an INFECTION |
| Where would you find MHC Class II antigens? From where do they come? | On some leukocytes; come from OUTSIDE a cell |
| What are the MHC Class II antigens? | B-cells, macrophages, and dendridic cells |
| ORIGIN OF T-CELLS | T-CELLS COME ABOUT |
| Where do t-cells get created? | Bone marrow |
| Where are they processed? | In the Thymus |
| What are the two steps inovolved with thymus processing? | Clonal expansion of cells reacting with MHC molecules and elimination of cells recognizing self |
| Why can't we make T-cells when we're older? | Because the thymus decreases in size, so no more new t-cells |
| Where do b and T cells go after they've matured in the bone marrow and thymus, respectively? | Go to spleen and lymph nodes |
| RESPONSE TO ANTIGEN | RESPONSE TO ANTIGEN |
| HELPER T-CELLS | HELPER T-CELLS |
| What is the T cell receptor for antigen? | MHC |
| What kind of a marker do helper t-cells have? | A protein CD4 marker |
| What is the purpose of the maker? | The marker is what sticks to the MHC Class II molecules |
| What does the first do? | Interacts with MACROPHAGES to activate them |
| What does the second do? | Interacts with B-CELLS to activate antibody response and, thus, formation of B-memory cells |
| CYTOTOXIC T-CELLS | KILLER T-CELLS |
| What kind of TCR do they need to be presented with? | MHC Class I |
| What kind of a marker do cytotoxic t-cells have? | A CD8 Protein |
| EVENTS IN RESPONSE TO ANTIGEN | I SAW AN ANTIGEN, NOW WHAT? |
| What are the seven steps involved in this response? | 1. Antigen presenting cells interact with antigen 2. APC go to lymph nodes 3. APC present antigen 4. Activate T-cell clones 5. Clonal explansion of T-cells 6. Immune T-cells return to circulation 7. Helper T-cells or C-T cells do stuff |
| CLONAL EXPANSION OF T-CELLS | Various responses described |
| What are Th1 cells? What are they fighting./what do they do? | Macrophage killing cells that help out CT cells |
| Whare are TH2 cells? What are they fighting? | Activate antibody response to rid of viruses |
| HELPER T-CELL ACTIVATION | HELPTER T-CELL ACTIVATION |
| What do helper t-cells activate? | macrophages and B-cells |
| Can you have unactivated macrophages? | Yeah, but they're not as good |
| Which type of T-cell function is most important to get a type I allergic response? | TH2 response |
| MECHANISM OF CELL ACTIVATION | CELL ACTIVATION STEPS |
| What does IL-1 activate? | lymphocytes |
| What does IL-2 activate? ANd what does the thing it activates requre activation by? | Role with T-cells |
| What does IL-8 activate? What does the thing it activates have a role with? | Neutrophils have a role in Chemotaxis |
| What does IL-12 activate? | Helpter T-cells |
| What are some examples of those cells? | Macrophages, CD8 T-cells, and NK cells |
| What is the function of TH2 cells? | Stimulates production of eosinophils, IgM, and IgE |
| Function of CT Cells? | Destroys target cells on contact |
| Function of Regulatory T cells? | Regulates immune response and helps maintain tolerance |
| Function of activated macrophages? | Better phagocytic activity to attack cancer cells |
| SUMMARY FUNCTIONS | SUMMARY FUNCTIONS |
| IL-2 | Role with T-cells |
| IL-8 | Chemotaxis for immune system cells and phagocytes to inflammation site |
| What induces a TH2? Th1> | TH2--B-cells; TH1-Macrophages |
| T independent antigens have what characteristics? | They have repeating antigens that activate B-cells to make Ab |
Created by:
talkglitter2486