Better Antibiotics
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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| What do antibiotics do? | -affect protein synthesis
-interact W cell membrane
-useful for ones that target bacteria wall
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| what antibiotic targets bacteria wall? | -penicillin
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| Effects of penicillin | -bacteria osmotically unstable
-lyse
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| Park nucleotides | -UDP W NAMA(short peptide) & NAG
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| UTP | -carrier of glycopeptides
-form rigid wall of bacteria
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| Bands of polysaccharides | -B1-4linkages
-btwn NAMA & NAG in 1 direction
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| Peptidoglycan | -rigid wall formed to prevent swelling/shrinking
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| penicillin on bacteria | -transpeptidase inhibitor
-blocks formation of X-links
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| B-lactam bond | -structural analogue of D-ala bond
-in penicillin
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| Co-existence of B-lactams & B-lactamases... | -indicates evolution of microorganisms which seek to secure own ecological niches against competitors
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| Vancomycin | -prevents hydrolsis & X-linking
-attaches to D-ala
-favoured->resistant strains are rare
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| Resistant transfer (Via sex-pilus) | -bacteria have plasmid with resistance
-transferred readily
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| Nucleotide analogues | -deficient nucleic acid
-inhibit polymerases
-effect R/DNA prod.
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| intercalating compounds | -stabilise helix
-harder to separate for DNA replication
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| Erythromycin | -translocation
-tetracycline
-Blocks site A
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| Chloramphenicol | -peptidyl transferase
-forms bonds between aa at A&P site
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| Mitochondrial ribosomes | -antibiotics effect these
-anaemia first sign
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Created by:
meglet
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